Protein Info for H281DRAFT_02226 in Paraburkholderia bryophila 376MFSha3.1

Annotation: penicillin-binding protein 2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 805 transmembrane" amino acids 20 to 42 (23 residues), see Phobius details TIGR03423: penicillin-binding protein 2" amino acids 17 to 625 (609 residues), 747.8 bits, see alignment E=4.5e-229 PF03717: PBP_dimer" amino acids 61 to 250 (190 residues), 144 bits, see alignment E=7.3e-46 PF00905: Transpeptidase" amino acids 283 to 621 (339 residues), 201.3 bits, see alignment E=2.1e-63

Best Hits

KEGG orthology group: K05515, penicillin-binding protein 2 (inferred from 89% identity to bug:BC1001_0064)

Predicted SEED Role

"Penicillin-binding protein 2 (PBP-2)" in subsystem Peptidoglycan Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (805 amino acids)

>H281DRAFT_02226 penicillin-binding protein 2 (Paraburkholderia bryophila 376MFSha3.1)
MTEFKDTQQQLSKFRLRVAAAGLFVFVCFGLIGFRFLFLQVWHYSKYSLQADENRISVAP
IVPNRGIITDRNGVVLAKNYSAYTLEITPSKLGAPLETVIDDLASVVSIDARDRRRFKKL
QEDSKNFESLPIRTRLTDDEVARFTAQRFRFPGVEVRARLFRQYPLGPTAAHVIGYIGRI
SQRDQDRIDDASDQNDSDPEHYDPRLDANNYKGTDYIGKIGVEQSYETELHGQTGFEEVE
VTAGGRPVRTMSRTQATPGNNLVLSLDIGLQQVAEQAFAGRRGALVAIEPATGDVLAFVS
APSFDPNSFVDGIDQQTWDELNNSPDHPLLNRPLHGTYPPGSTYKPFMALAALSLHKRTP
GWGFQDPGSYTFGGHTFRNDVRSGQGWVDMNRAIVVSNDTYFYMLAHDLGVNAIAGFMKP
WGFGQITGIDISGEARGILPSTEWKRKAYRKPEQQRWYEGETISLGIGQGYNSFTILQLA
HATATLANNGVVMKPHLVRDIENPITKGTRPVVRDPSDKIAVKQSDIDIIKRAMEGVITN
GTASKLFIGAPYVAAGKTGTAQVYSLQGANYKGHAIAEHLRDHALFIAFAPAEQPKIALA
LIVENGGWGAEAAGPIARKVLDYYLVGKNKPGAEAAAVAAAASATEDASAPEVGGAPAPQ
EAGQPVRIAAGFAALPMPGAASAAAAASAAAAAAAANGASGAGAASGAAAASAVTPTSKL
SASTATPATTPKLPASATAATAGTPASAAKGSVPRKTGAPRQPRPASEPAPVAARSGTSM
LRDPSRDNGTQATSPRQPVTGGIDE