Protein Info for H281DRAFT_02214 in Paraburkholderia bryophila 376MFSha3.1

Annotation: homoserine O-acetyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 98% identical to METXS_PARPJ: Homoserine O-succinyltransferase (metXS) from Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)

KEGG orthology group: K00641, homoserine O-acetyltransferase [EC: 2.3.1.31] (inferred from 97% identity to bug:BC1001_0076)

Predicted SEED Role

"Homoserine O-acetyltransferase (EC 2.3.1.31)" in subsystem Methionine Biosynthesis (EC 2.3.1.31)

MetaCyc Pathways

superpathway of L-methionine biosynthesis (by sulfhydrylation) (11/12 steps found)
L-homocysteine biosynthesis (2/2 steps found)
L-methionine biosynthesis III (3/4 steps found)
superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (7/10 steps found)
superpathway of L-cysteine biosynthesis (fungi) (3/6 steps found)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.31

Use Curated BLAST to search for 2.3.1.31

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5M956 at UniProt or InterPro

Protein Sequence (381 amino acids)

>H281DRAFT_02214 homoserine O-acetyltransferase (Paraburkholderia bryophila 376MFSha3.1)
MESIGIVAPQKMHFTEPLRLQNGSSLASYDLMVETYGTLNAARSNAVLVCHALNASHHVA
GVYADNLKDIGWWDNMVGPGKPLDTNKFFVIGVNNLGSCFGSTGPMSIDPATGNPYGATF
PVVTVEDWVNAQARVADQFGITRFAAVMGGSLGGMQALAWSMMYPERVGHCIVVASTPKL
SAQNIAFNEVARSAILSDPDFHGGNYYAHNVKPKRGLRVARMIGHITYLSDDDMAEKFGR
SLRRAEGALDAYNFNFDVEFEVESYLRYQGDKFADYFDANTYLLITRALDYFDPAKAFEG
DLTAAVAHTTAKYLIASFTTDWRFAPARSRELVKALLDHKRTVTYAEIDAPHGHDAFLLD
DARYHNLMRAYYERIANEVNA