Protein Info for H281DRAFT_02115 in Paraburkholderia bryophila 376MFSha3.1

Annotation: diguanylate cyclase/phosphodiesterase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 618 PF00563: EAL" amino acids 15 to 243 (229 residues), 154.3 bits, see alignment E=3.7e-49 PF00990: GGDEF" amino acids 441 to 505 (65 residues), 45 bits, see alignment E=1e-15 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 446 to 511 (66 residues), 42.2 bits, see alignment E=3.5e-15

Best Hits

KEGG orthology group: None (inferred from 93% identity to bgf:BC1003_0176)

Predicted SEED Role

"FOG: EAL domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5M7J9 at UniProt or InterPro

Protein Sequence (618 amino acids)

>H281DRAFT_02115 diguanylate cyclase/phosphodiesterase (Paraburkholderia bryophila 376MFSha3.1)
MQLRSPSGIAAPRIEDLIARRDLSAVFQPIIDFEDGAILGYEGLIRGPAGTSLETPFALF
SQALVEGCTIELEQAAARACIDAFARLGYDGKLFLNFSAGALRRLAAVPDDTLALLRHRG
VDPQRIVIELTEQSMIPDIGSFLPVIASLRTAGAQFALDDYGTANASMNLWVRLQPDVVK
IDRFFIHDIACDPLKFEAVRAMQHFASASGARLVAEGIENEADLIVVRDMGIGCGQGFFF
GRPHAQPASKVTDDARDALRAGHIAVFPEATRTLGGASPSGGMASEKMLVHAPALPRQAT
NNDVLELFNRLPDLHAVAVVEHDEPVALINRRSFMDRYALPYHRELFGKRPCLLFANASP
VVIEKSMTVEQMAKLLASDDQRYLADGFVITENGKYAGLGTGENLVRAVTEVRIEAARYA
NPLTFLPGNIPISSHIARLVGNHAGFYACYVDLNHFKPFNDQYGYWQGDEVLKFAAAVLA
DVCDPTRDFLGHVGGDDFLILFQSDDWRERVLRAIHVFNEGAQRFYAPTDRLAGGIHGED
RRGNPTFFGFVTMAIGCVRVEPEPAGGASLYNSEEIATVAALAKRRAKLEPSGFVLIDAE
ESVALLRGQSDATATSAD