Protein Info for H281DRAFT_02110 in Paraburkholderia bryophila 376MFSha3.1
Annotation: methylmalonyl-CoA mutase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K11942, methylmalonyl-CoA mutase [EC: 5.4.99.2] (inferred from 69% identity to eba:ebA3766)Predicted SEED Role
"B12 binding domain / kinase domain / Methylmalonyl-CoA mutase (EC 5.4.99.2)" in subsystem Propionyl-CoA to Succinyl-CoA Module or Serine-glyoxylate cycle (EC 5.4.99.2)
MetaCyc Pathways
- superpathway of anaerobic energy metabolism (invertebrates) (14/17 steps found)
- propanoyl CoA degradation I (2/3 steps found)
- anaerobic energy metabolism (invertebrates, mitochondrial) (7/10 steps found)
- 2-oxobutanoate degradation I (2/4 steps found)
- conversion of succinate to propanoate (1/3 steps found)
- 3-hydroxypropanoate cycle (8/13 steps found)
- methylaspartate cycle (12/19 steps found)
- pyruvate fermentation to propanoate I (3/7 steps found)
- superpathway of the 3-hydroxypropanoate cycle (10/18 steps found)
- 3-hydroxypropanoate/4-hydroxybutanate cycle (9/18 steps found)
- (S)-lactate fermentation to propanoate, acetate and hydrogen (5/13 steps found)
- superpathway of L-methionine salvage and degradation (7/16 steps found)
- L-glutamate degradation VIII (to propanoate) (3/11 steps found)
- crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered) (3/14 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 5.4.99.2
Use Curated BLAST to search for 5.4.99.2
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (1132 amino acids)
>H281DRAFT_02110 methylmalonyl-CoA mutase (Paraburkholderia bryophila 376MFSha3.1) MTDLSTPQRAASHELPAGRRLRFVTAAALFDGHDASINIMRRILQASGVEVIHLGHNRSV DEVATAALQEDADGVAVSSYQGGHNEYFRYLVDLLRARGGERIKVFGGGGGVIVSEEIVA LENYGVEKIYSPHDGQRLGLQGMIDDMIARCSAAAREDATARTGAVGEWLASVTGQPLLH LRSSAQVRGETSSADSLDASSLVFRRLAQLISAFETGGVASSKRAELSALTQAVQVPVLG ITGTGGAGKSSLTDELIRRFRLDYGDTLTIAVLAIDPSRRKSGGALLGDRIRMNAIGDWG GGARVYMRSMATREASSEISDALPDALMLCKAAGFDLIVVETSGIGQGDAAIVPFVDESL YVMTPEFGAASQLEKIDMLDFADAVAINRFDRKGAPDALRDVAKQVQRNRADFAKSPEAM PVFGTIASHFNDDGVTALYQYIAEALRKHGLRSGGGRLSIAADVRFSSGRHAIVPPARVR YLAEIAQTIHAYRERVDQQAGVARERWQLVEARRMLGEASADAHDAQASLASLDALIEQR TTALGEHERKLLDAWPQTVAAYSGDDHVVRIRDREIRTALTATTLSGTQLRKVALPKFVD HGEILRWLMLDNLPGYFPFTAGVFPFRRENEDPTRMFAGEGDPSRTNRRFKLLSEGMPAK RLSTAFDSVTLYGEEPDERPDIYGKVGNSGVSVATLDDMHALYDGFDLCAPQTSVSMTIN GPAPTILAMFFNVAIDQQIARQAQQLGRALSEDELAETRRMALENVRGTVQADILKEDQG QNTCIFSTEFSLKVMGDIQAYFVEHRVRNFYSVSISGYHIAEAGANPISQLAYTLANGFT YVEAYLARGMSIDDFAPNLSFFFSNGMDPEYTVLGRVARRVWAIAMRERYGANERSQKLK YHVQTSGRSLHAQEIDFNDIRTTLQALIAIYDNCNSLHTNAFDEAITTPTEESVRRAVAI QLIINREWGLAKNQNPNQGSFVIDELTDLVEEAVLAEFDRLTERGGVLGAMETGYQRGRI QDESMLYEHRKHDGSYPIVGVNTFVSAKPHEAPTPIALARSTEEEKQSQLKRLRDFQARH RGAAPAALERLQRAVIDDENVFAVLMDVVRVCSLGQITHALFEVGGQYRRNM