Protein Info for H281DRAFT_01985 in Paraburkholderia bryophila 376MFSha3.1

Annotation: protoheme IX farnesyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 301 transmembrane" amino acids 25 to 43 (19 residues), see Phobius details amino acids 49 to 71 (23 residues), see Phobius details amino acids 92 to 113 (22 residues), see Phobius details amino acids 119 to 139 (21 residues), see Phobius details amino acids 146 to 167 (22 residues), see Phobius details amino acids 173 to 194 (22 residues), see Phobius details amino acids 215 to 236 (22 residues), see Phobius details amino acids 242 to 263 (22 residues), see Phobius details amino acids 275 to 295 (21 residues), see Phobius details TIGR01473: protoheme IX farnesyltransferase" amino acids 16 to 293 (278 residues), 317 bits, see alignment E=7.3e-99 PF01040: UbiA" amino acids 29 to 277 (249 residues), 226.2 bits, see alignment E=2e-71

Best Hits

Swiss-Prot: 95% identical to COXX_PARXL: Protoheme IX farnesyltransferase (ctaB) from Paraburkholderia xenovorans (strain LB400)

KEGG orthology group: K02301, protoheme IX farnesyltransferase [EC: 2.5.1.-] (inferred from 94% identity to bge:BC1002_0279)

MetaCyc: 33% identical to heme O synthase (Escherichia coli K-12 substr. MG1655)
HEMEOSYN-RXN [EC: 2.5.1.141]

Predicted SEED Role

No annotation

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.5.1.-

Use Curated BLAST to search for 2.5.1.- or 2.5.1.141

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5M7F5 at UniProt or InterPro

Protein Sequence (301 amino acids)

>H281DRAFT_01985 protoheme IX farnesyltransferase (Paraburkholderia bryophila 376MFSha3.1)
MDSTTLPHTPGSRISQYIALTKPRVTQLAVFCAVIGMFLSTPGMVPWTVLIGGTVGIWLL
AGAAFAINCLVEQKIDAKMRRTSWRPSARGEITTTQILLFSAVLGGLGMWTLYTFANPLT
MWLTLATFVGYAVIYTLLLKPATPQNIVIGGASGAMPPALGWAAVTGQVPGDAWILVLII
FVWTPPHFWALALYRRKDYENAGLPMLPNTHGEKYTRLHILLYTVILFAVTMMPFISGMS
GVLYLAAAVVLGAVFLAYAWKIYLEYSDNLARRTFRYSIVYLSLLFAALLVDHYVRVVIG
A