Protein Info for H281DRAFT_01833 in Paraburkholderia bryophila 376MFSha3.1

Annotation: aldehyde dehydrogenase (NAD+)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 19 to 477 (459 residues), 451.2 bits, E=1.8e-139

Best Hits

Swiss-Prot: 51% identical to AL7A1_HUMAN: Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) from Homo sapiens

KEGG orthology group: None (inferred from 96% identity to bgf:BC1003_4459)

MetaCyc: 68% identical to L-aminoadipate-semialdehyde dehydrogenase (Pseudomonas putida)
L-aminoadipate-semialdehyde dehydrogenase. [EC: 1.2.1.31]

Predicted SEED Role

"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)

MetaCyc Pathways

• methylglyoxal degradation V (2/3 steps found)
• L-lactaldehyde degradation (aerobic) (1/2 steps found)
• lactate biosynthesis (archaea) (3/5 steps found)
• L-rhamnose degradation II (5/8 steps found)
• methylglyoxal degradation IV (1/3 steps found)
• superpathway of methylglyoxal degradation (4/8 steps found)
• superpathway of fucose and rhamnose degradation (5/12 steps found)
• L-lysine degradation V (2/9 steps found)
• superpathway of L-lysine degradation (11/43 steps found)

KEGG Metabolic Maps

• Lysine biosynthesis
• Lysine degradation
• Pyruvate metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.22

Use Curated BLAST to search for 1.2.1.22 or 1.2.1.31

Protein Sequence (499 amino acids)

>H281DRAFT_01833 aldehyde dehydrogenase (NAD+) (Paraburkholderia bryophila 376MFSha3.1)
VKASAILSELGISHLAEAGDIAVHSPINGELIGRVASRTVAEVDAALASAQKAYASWRNV
PAPRRGELVRLLGNKLREQKHALGSIITLETGKILQEGLGEVQEMIDICDFAVGLSRQLY
GLTIASERPGHRMAETWHPLGVCTVISAFNFPAAVWSWNAALALVCGNAVVWKPSEKTPL
TALAVDKILQDALKEFGDAPEGLTSVVNGGREVGAKLVADPRSNIVSATGSTEMGRAVGV
EVARRFGRSILELGGNNAGIVSGSADMELALRGIVFSAVGTAGQRCTSLRRLFVHESVYD
KAVERLKALYSKVVIGNPLEQGVLMGPLIDEQSFNRMQAALEQAKSEGGKVFGGERHAVA
GNEKGFYVRPAIVEMPSQTSVVLKETFAPILYVLKYSDFDDAIGGNNAAVHGLSSCVFTT
DLREAERFLSASGSDCGIANVNIGPSGAEIGGAFGGEKETGGGRESGSDSWKAYMRRATN
TVNYSSALPLAQGIDFNIG