Protein Info for H281DRAFT_01779 in Paraburkholderia bryophila 376MFSha3.1

Annotation: DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 458 PF00072: Response_reg" amino acids 4 to 116 (113 residues), 84.6 bits, see alignment E=1.4e-27 PF00158: Sigma54_activat" amino acids 149 to 314 (166 residues), 236.5 bits, see alignment E=3.4e-74 PF14532: Sigma54_activ_2" amino acids 149 to 319 (171 residues), 74.2 bits, see alignment E=3.2e-24 PF07728: AAA_5" amino acids 172 to 290 (119 residues), 29.2 bits, see alignment E=2.1e-10 PF02954: HTH_8" amino acids 415 to 454 (40 residues), 45 bits, see alignment 1.8e-15

Best Hits

KEGG orthology group: None (inferred from 82% identity to bpy:Bphyt_6059)

Predicted SEED Role

"Response regulator of zinc sigma-54-dependent two-component system" in subsystem Zinc resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MM32 at UniProt or InterPro

Protein Sequence (458 amino acids)

>H281DRAFT_01779 DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains (Paraburkholderia bryophila 376MFSha3.1)
MAHILVVDDDNGFREGLVETLVDLGHSVDEARSGEQALEMLESTGAPFTCMFLDFRLPGM
DGLAVLDALRKTAKGQALPVVMLTGFASSDNTIGAMTLGAFDHLTKPVGRQAIQALLARI
IASTGTIDSAANASHPFSAESAGAKPRLLGVSETLREVQKQIGRAASSEATVLFTGETGT
GKEVAARVLHDASRRSGKPFVAVNCAAIPAELLESELFGHVKGAFTGATADRPGCFAAAD
GGTLLLDEIGDMPLPMQAKLLRVIQERQITPLGSNRVIPVDIRLVAATHRNLQTMVEAGE
FREDLLYRLNIIPIALPPLRERLADILPLAEHFLAEVAKARSRELRLSLPAQHLLVGYAW
PGNVRELRNAVERAGALAPGAMITAEDLGFLNGKPDLGEPLVGTGLLEMTLPDAVETLER
ALISHALTLASNNRADAARRLGISRQTLYAKLAALKIE