Protein Info for H281DRAFT_01679 in Paraburkholderia bryophila 376MFSha3.1

Annotation: shikimate dehydrogenase (EC 1.1.1.25)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00507: shikimate dehydrogenase
  • amino acids 5 to 272 (268 residues), 247.5 bits, E=7e-78
• PF08501: Shikimate_dh_N
  • amino acids 7 to 91 (85 residues), 75.6 bits, E=4.6e-25
• PF01488: Shikimate_DH
  • amino acids 120 to 197 (78 residues), 37 bits, E=5.1e-13
• PF18317: SDH_C
  • amino acids 243 to 272 (30 residues), 35.4 bits, see alignment (E = 1.1e-12)

Best Hits

Swiss-Prot: 53% identical to AROE_AROAE: Shikimate dehydrogenase (NADP(+)) (aroE) from Aromatoleum aromaticum (strain EbN1)

KEGG orthology group: K00014, shikimate dehydrogenase [EC: 1.1.1.25] (inferred from 85% identity to bmj:BMULJ_05404)

Predicted SEED Role

"Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) (EC 1.1.1.25)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• chorismate biosynthesis I (7/7 steps found)
• chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
• superpathway of chorismate metabolism (43/59 steps found)
• chorismate biosynthesis II (archaea) (8/12 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.25

Use Curated BLAST to search for 1.1.1.25

Sequence Analysis Tools

See A0A2Z5MJW1 at UniProt or InterPro

Protein Sequence (277 amino acids)

>H281DRAFT_01679 shikimate dehydrogenase (EC 1.1.1.25) (Paraburkholderia bryophila 376MFSha3.1)
MSDRYAVIGNPIGHTKSPLIHGLFAEETGQDMTYDAIEGPLEPANAFDDTVRTFIAAGGK
GMNVTAPFKLQAFAVADERSERAALAGAVNAMKFENGRIVAENFDGVGLVRDIEINLHQP
MAGKRVLVLGAGGAVRGALLPFIAARPARLVIANRHVDKAKALVEQVAADATLVACGYAE
LESMGQFDLVVNATSASLTGQRPPVPPSVFSASGTAYELAYGKGLTPFLRLARHAGVQGV
ADGVGMLVEQAAEAFAWWRGVRPRTHAIIDQLTVPLD