Protein Info for H281DRAFT_01574 in Paraburkholderia bryophila 376MFSha3.1

Annotation: CubicO group peptidase, beta-lactamase class C family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 437 signal peptide" amino acids 1 to 32 (32 residues), see Phobius details PF00144: Beta-lactamase" amino acids 53 to 418 (366 residues), 198.5 bits, see alignment E=8.3e-63

Best Hits

KEGG orthology group: None (inferred from 76% identity to bpy:Bphyt_6425)

MetaCyc: 43% identical to methyl acetate hydrolase (Gordonia sp. TY-5)
RXN-17572 [EC: 3.1.1.114]

Predicted SEED Role

"Beta-lactamase class C and other penicillin binding proteins" in subsystem Beta-lactamase

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.1.114

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (437 amino acids)

>H281DRAFT_01574 CubicO group peptidase, beta-lactamase class C family (Paraburkholderia bryophila 376MFSha3.1)
MAVQTDRRRLLKGASSLLALATLGGVASRDARAVSPRASGDAALARHPAYRSIDQCLQRA
VNDGAVAGVVAMGATDRGLVYEGACGRANARTGEAISPDTVFWLLSMTKAITATACMQLI
EQGRLRLDQPAGEILPQLKSPQILDGFDVSGQPKLRPARNAITVRHLLTHTSGFTYSIWS
DKLSRYETVTGMPDIGYSMNGAFAAPLEFEPGERWEYGISMDWVGKLVEAVTDQSLEVYF
REHIFDPLSMRNTGFLIGSEQKQRVATMHRRQADGSLAPEPFETNQRPEFFMGGGGLFST
PRDYMAFLQMLLNGGTYRGERVLRADTVATMFRNHIGDLQVAEMRTAQPSWSNSFDQFPG
TAHKWGLSFDINTEQGPHGRSAGSVSWAGLLNTYFWVDPVKRVAGSLFTQMLPFYDARVV
DLYGQFEKAFYDGLRRA