Protein Info for H281DRAFT_01519 in Paraburkholderia bryophila 376MFSha3.1
Annotation: fructuronate reductase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 39% identical to M2DH_ASPFC: Mannitol 2-dehydrogenase (AFUB_071700) from Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)
KEGG orthology group: K00040, fructuronate reductase [EC: 1.1.1.57] (inferred from 80% identity to bpy:Bphyt_4721)Predicted SEED Role
"D-mannonate oxidoreductase (EC 1.1.1.57)" in subsystem D-Galacturonate and D-Glucuronate Utilization (EC 1.1.1.57)
MetaCyc Pathways
- D-fructuronate degradation (4/4 steps found)
- superpathway of β-D-glucuronosides degradation (5/7 steps found)
- superpathway of hexuronide and hexuronate degradation (7/10 steps found)
- superpathway of microbial D-galacturonate and D-glucuronate degradation (20/31 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.57
Use Curated BLAST to search for 1.1.1.57
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (498 amino acids)
>H281DRAFT_01519 fructuronate reductase (Paraburkholderia bryophila 376MFSha3.1) MSTPASLPRLTRHALSALSQHVLSSEHAAWREPSIGIVHLGIGNFHRAHQALYTEEAMLA EGGDWGICGVTLQGDVAKRNALMEQEGVYSVVERGPEGAKVTVVRALREVLAMPHDHDAL FARLADPSVRIVSLTVTEKGYCRNAKTGDVALDNPAVVHDLSHPHAPRSVPGILVAALRQ RRDAAREPFTVLSCDNLAHNGAALRQVVCSFAREFDPALADWIAVEVAFPSTMVDRIAPA TTDFEHATVAAALGYRDAAPVPCEPFRQWVIEDRFPAGRPAWHAVGAQLVDDVTPFELAK LRMLNGTHSTLAYLSMLGGFTTIDEAIADPAMRNLIHAMMTEEIAPTLNMPASFDVANYR DALLARYANPALKHRCAQIAMDGSQKIPPRLLGTIAARIDAGQPFTRLALAVAGWMTFLR GYADDGSRYDISDPLAENLKALAASANGDPRALMDTLLGVREIFTAELAAQPAFRAALLH ALQLLQDNGARAAVAALQ