Protein Info for H281DRAFT_01518 in Paraburkholderia bryophila 376MFSha3.1
Annotation: D-mannonate dehydratase (EC 4.2.1.8)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 78% identical to MAND_ESCAT: D-galactonate dehydratase family member RspA (rspA) from Escherichia albertii (strain TW07627)
KEGG orthology group: K08323, starvation sensing protein RspA (inferred from 97% identity to bpy:Bphyt_4722)Predicted SEED Role
"Starvation sensing protein RspA"
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A2Z5MLE9 at UniProt or InterPro
Protein Sequence (402 amino acids)
>H281DRAFT_01518 D-mannonate dehydratase (EC 4.2.1.8) (Paraburkholderia bryophila 376MFSha3.1) MKIVRADVIVTCPGRNFVTLKIVTDEGVHGIGDATLNGRELAVASYLKDHVCPLLIGRDP GRIEDTWQYLYKGAYWRRGPVTMTAIAAVDMALWDILGKVTGMPLYKLLGGASREGVMVY GHATGRDIPEALDRYAEHIEAGYQAIRIQCGVPNMRSVYGVSKGSGMYEPATKGAVEEQS WSSEKYLDFVPKLFEAVREKFGFDTHLLHDVHHRLTPIEAARLGKSVEPYRLFWMEDPTP AENQAGFRLIREHTVTPIAVGEVFNSIWDCKQLIEEQLIDYIRATLTHAGGISHLRRIAD FASLYQVRTGCHGPSDLSPVCMGAALHFDLWVPNFGVQEYMGFPEEALEVFPHAWRFDHG MMHPGDAPGHGVDIDEAAAARFPYDPAYLPVARLEDGTLWSW