Protein Info for H281DRAFT_01475 in Paraburkholderia bryophila 376MFSha3.1

Annotation: isoquinoline 1-oxidoreductase, beta subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 740 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details PF20256: MoCoBD_2" amino acids 32 to 202 (171 residues), 69.2 bits, see alignment E=4.3e-23 amino acids 604 to 687 (84 residues), 70.6 bits, see alignment E=1.7e-23 PF02738: MoCoBD_1" amino acids 326 to 563 (238 residues), 108 bits, see alignment E=4.4e-35

Best Hits

KEGG orthology group: K07303, isoquinoline 1-oxidoreductase, beta subunit [EC: 1.3.99.16] (inferred from 94% identity to bgf:BC1003_2374)

Predicted SEED Role

"Isoquinoline 1-oxidoreductase beta subunit (EC 1.3.99.16)" in subsystem N-heterocyclic aromatic compound degradation (EC 1.3.99.16)

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.16

Use Curated BLAST to search for 1.3.99.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MLJ3 at UniProt or InterPro

Protein Sequence (740 amino acids)

>H281DRAFT_01475 isoquinoline 1-oxidoreductase, beta subunit (Paraburkholderia bryophila 376MFSha3.1)
MTTGSDLTDAVRPSRRTFLKAAGAVAAVGANIGLTIGFEWAGMGRRALAATMPDATFAPN
AFLRVAPDNSVTVIAKHVEMGQGAYTGIATIVAEELDANWQDVRVESAPADAKRYANLAF
GTMQGTGGSSAMANSWMQLREAGAKARAMLVSAAAAQWQVPATELVTRDGSVHHAATNRS
ATYGSLASAAARLPVPQKVALKSPKDFRLIGHQLPRVDVPPKTDGTAQFTLDVTFPGMLV
ALLQRPPLFGATVKSFDASAAKAVPGVVSVVQVPGGVAVVAKGFWAAKQGRDALKVEWDD
SKAEKRSSDAIMAEYRRLAEQPGATARKDGNAEQALSGAAKKISASYSFPYLAHAPMEPL
DAVVKLTANSCEIWAGDQFQTVDQANAARTAGLDPQQVKIYTLYAGGSFGRRANTRSDYI
VEAVSIARALGANGTPVKLQWTREDDIHGGLYRPMYFHKLDAGLTADGKLVGWRHRIVGQ
SILGDTPFASVMVKNGIDATSVEGAANLAYAIPNISVELTTTQTGVPVLWWRVVGSSHTA
FAVEAFIDEAAHAAGKDPFAFRRDLLAHEPRMRAVLELAAQKAGWDPAKPLPKGRGRGIA
VAEAFKTFVAQVAEVSVDQDGNVKVERVVCAVDCGTPINPDVIAAQMEGGIGFGLGAALH
SAITLKDGKVEQNNFDSYQVLRIAEMPKVEVHIVQSGEAPTGVGEPGVAPVGPAVANAIF
AATGKRLYDLPFPAAAGKTD