Protein Info for H281DRAFT_01346 in Paraburkholderia bryophila 376MFSha3.1

Annotation: isovaleryl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 393 PF02771: Acyl-CoA_dh_N" amino acids 13 to 124 (112 residues), 148.1 bits, see alignment E=2.5e-47 PF02770: Acyl-CoA_dh_M" amino acids 128 to 223 (96 residues), 96.7 bits, see alignment E=1.5e-31 PF00441: Acyl-CoA_dh_1" amino acids 235 to 388 (154 residues), 131.1 bits, see alignment E=7.8e-42 PF08028: Acyl-CoA_dh_2" amino acids 257 to 371 (115 residues), 50.6 bits, see alignment E=5e-17

Best Hits

Swiss-Prot: 68% identical to IVD_SOLTU: Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) from Solanum tuberosum

KEGG orthology group: None (inferred from 99% identity to bgf:BC1003_5409)

Predicted SEED Role

"Isovaleryl-CoA dehydrogenase (EC 1.3.8.4); Acyl-CoA dehydrogenase, short-chain specific (EC 1.3.8.1)" (EC 1.3.8.1, EC 1.3.8.4)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.3.8.4

Use Curated BLAST to search for 1.3.8.1 or 1.3.8.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MN57 at UniProt or InterPro

Protein Sequence (393 amino acids)

>H281DRAFT_01346 isovaleryl-CoA dehydrogenase (Paraburkholderia bryophila 376MFSha3.1)
MSNLPGLQFPLGEEIEMLRDSIAGFAAKEIAPRAAEIDRTDQFPMDLWRKFGDLGVLGMT
VSEEYGGANMGYTAHMVAMEEISRASASVGLSYGAHSNLCVNQIHRNGTEAQKQKYLPKL
VSGEHVGALAMSEPNAGSDVVSMKLRADRKGDRYVLNGTKMWITNGPDCDTLVVYAKTDV
EANSRGITAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFQDVEVPEENILGQLNGGVKV
LMSGLDYERAVLAGGPTGIMVAVMDAVVPYIHDRKQFGQSIGEFQLIQGKVADLYTTLQA
CRAYLYAVGRQLDTLGTAHVRQVRKDCAGVILYTAEKATWMAGEAIQILGGNGYINEYPV
GRLWRDAKLYEIGAGTSEIRRMLIGRELFAETA