Protein Info for H281DRAFT_01331 in Paraburkholderia bryophila 376MFSha3.1

Annotation: pyrroloquinoline-quinone synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 TIGR02111: coenzyme PQQ biosynthesis protein C" amino acids 27 to 248 (222 residues), 342.6 bits, see alignment E=5.7e-107 PF03070: TENA_THI-4" amino acids 33 to 242 (210 residues), 196.2 bits, see alignment E=3.2e-62

Best Hits

Swiss-Prot: 68% identical to PQQC_PSEA8: Pyrroloquinoline-quinone synthase (pqqC) from Pseudomonas aeruginosa (strain LESB58)

KEGG orthology group: K06137, pyrroloquinoline-quinone synthase [EC: 1.3.3.11] (inferred from 92% identity to bug:BC1001_3978)

MetaCyc: 66% identical to pyrroloquinoline-quinone synthase monomer (Klebsiella pneumoniae)
Pyrroloquinoline-quinone synthase. [EC: 1.3.3.11]

Predicted SEED Role

"Pyrroloquinoline-quinone synthase (EC 1.3.3.11)" (EC 1.3.3.11)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.3.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (250 amino acids)

>H281DRAFT_01331 pyrroloquinoline-quinone synthase (Paraburkholderia bryophila 376MFSha3.1)
MNAKDTLSAAPHNTAGSGEKPGDEAWTREEFEAQLRAKGTAYHIHHPFNVKMNSGGCSRE
QIRGWVANRFYYQINIPLKDAAVLSNCPDRETRRRWVLRILDHDGYGDEEGGIETWARLG
DAVGLSRDELWSLKHVTPGVRFAVDAYVNFARRAPWQESVCSSLTEMFAPQVHRDRLASW
PEHYPWIEASGLAYFRSRITLAQRDVEHGLQVTLDHFTRREQQERALEILQFKLDILWTM
LDSIEKAFPQ