Protein Info for H281DRAFT_01278 in Paraburkholderia bryophila 376MFSha3.1
Annotation: trans-feruloyl-CoA synthase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K12508, feruloyl-CoA synthase [EC: 6.2.1.34] (inferred from 89% identity to bug:BC1001_3919)MetaCyc: 52% identical to 4-coumarate-CoA ligase (Rhodopseudomonas palustris CGA009)
4-coumarate--CoA ligase. [EC: 6.2.1.12]
Predicted SEED Role
"Trans-feruloyl-CoA synthase (EC 6.2.1.34)" (EC 6.2.1.34)
MetaCyc Pathways
- ferulate degradation (3/3 steps found)
- 4-hydroxybenzoate biosynthesis III (plants) (4/5 steps found)
- umbelliferone biosynthesis (2/3 steps found)
- 6-gingerol analog biosynthesis (engineered) (3/6 steps found)
- 4-coumarate degradation (aerobic) (2/5 steps found)
- naringenin biosynthesis (engineered) (1/4 steps found)
- xanthohumol biosynthesis (1/4 steps found)
- 4-coumarate degradation (anaerobic) (2/6 steps found)
- chlorogenic acid biosynthesis II (1/5 steps found)
- flavonoid biosynthesis (1/5 steps found)
- phaselate biosynthesis (1/5 steps found)
- coumarins biosynthesis (engineered) (5/13 steps found)
- chlorogenic acid biosynthesis I (1/8 steps found)
- rosmarinic acid biosynthesis I (2/10 steps found)
- avenanthramide biosynthesis (1/9 steps found)
- curcuminoid biosynthesis (1/10 steps found)
- superpathway of rosmarinic acid biosynthesis (3/14 steps found)
- flavonoid di-C-glucosylation (3/15 steps found)
- monolignol biosynthesis (1/15 steps found)
- suberin monomers biosynthesis (3/20 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of phenylpropanoids
- Phenylpropanoid biosynthesis
- Ubiquinone and menaquinone biosynthesis
Isozymes
No predicted isozymesUse Curated BLAST to search for 6.2.1.12 or 6.2.1.34
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A2Z5MIR3 at UniProt or InterPro
Protein Sequence (629 amino acids)
>H281DRAFT_01278 trans-feruloyl-CoA synthase (Paraburkholderia bryophila 376MFSha3.1) VNLQPTQSSVDRETPVRYREVRIGSAPARVRRDGDVWYMESAAMPGNYPQRLTDRLASGA RAHPDRWLVARRGANGEWQGISYAQMLQRARAIGQALLERNLSAERPVAILSGNDLEHMM IALGAMWAGVPYAPISPAYSLVSSDFGKLRHTLDVLTPGLVFATDASAFAAAIDATVAAD VEVVTSTGCCARPVTKLSALLDTTPVTVDAAHEAIDPDSIAKFLFTSGSTTLPKAVPTTH RMLCSNQQMLRETFPEFADEPPVLVDWLPWNHTFGGSHNAGIALYNGGTLYIDDGKPVGK KFEETLRNLREIAPTIYFNVPKGWEELTSALETDAKLRETFFSRVKVYFFAGAGLSQAAW DRLQQVTERFCGERIRIMAGLGMTETSPSCLFTTLPAKAAGYVGVPAPGCEVKLVPIGDK LEARFRGPHVMRGYWRMDGAATGKSFDDEGYYCSGDALKFVDPQQPELGLMFDGRIAEDF KLSSGTFVSVGPMRARVISAGAPYVQDVVVSGLNCDDVGLLVFPRLDDCRRLAQLPSSAS ASEVVSAPAVRQFFVELLDRLNRESTGGATTIARMRLLDVAPSLDLGEITDKGSINQRAV LSHRAELVQALHDPIQRDPAVIYAPHVRT