Protein Info for H281DRAFT_01277 in Paraburkholderia bryophila 376MFSha3.1
Annotation: vanillin dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 70% identical to VDH_PSEFL: Vanillin dehydrogenase (vdh) from Pseudomonas fluorescens
KEGG orthology group: None (inferred from 92% identity to bug:BC1001_3918)MetaCyc: 70% identical to vanillin dehydrogenase (Pseudomonas sp. HR199)
Vanillin dehydrogenase. [EC: 1.2.1.67]
Predicted SEED Role
"Probable VANILLIN dehydrogenase oxidoreductase protein (EC 1.-.-.-)" in subsystem Phenylpropanoid compound degradation (EC 1.-.-.-)
MetaCyc Pathways
- vanillin and vanillate degradation II (2/2 steps found)
- superpathway of vanillin and vanillate degradation (7/10 steps found)
- vanillin and vanillate degradation I (1/2 steps found)
- 4-coumarate degradation (aerobic) (2/5 steps found)
- 4-coumarate degradation (anaerobic) (2/6 steps found)
- pinoresinol degradation (2/10 steps found)
KEGG Metabolic Maps
- 2,4-Dichlorobenzoate degradation
- Alkaloid biosynthesis I
- Biosynthesis of phenylpropanoids
- Carotenoid biosynthesis - General
- Insect hormone biosynthesis
- Nucleotide sugars metabolism
- Porphyrin and chlorophyll metabolism
- Puromycin biosynthesis
- Trinitrotoluene degradation
- alpha-Linolenic acid metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.-.-.-
Use Curated BLAST to search for 1.-.-.- or 1.2.1.67
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A2Z5MKA5 at UniProt or InterPro
Protein Sequence (483 amino acids)
>H281DRAFT_01277 vanillin dehydrogenase (Paraburkholderia bryophila 376MFSha3.1) VNEVSMLIGGKDCPASGGATFERIDPVTGGVASRAPAATLADADAAVEAAAAAFPAWSAL RPTERRARLLKAADIMDARAGAFIECGMAETGAMANWYGFNVHLAANMLREAAAMTTQID GSVIPTDTPDNIALAVRQPCGVVLGIAPWNAPVILGTRAVAMPLACGNTVVLKASEACPA VHRMIGSVLQDAGLGDGVVNVVTNAPDDAPAIVERLIAHPAVRRVNFTGSTHVGRIIAMH AAKHLKPALLELGGKAPVLVLEDADLDAAVDAIAFGAFFNQGQICMSTERVIAHRSVADA LVDKLAEKARTLVAGAPNAKDAKLGAMVSAQAAQRATALVQDAREHGAKVLGGGALTGAI MQPTIVDGVLPAMKLYAEESFAPVVTVLRVDTDDEAVKVANDSEFGLSAAVFSRDIARAM SVAKRVESGICHINGPTVHDEAQMPFGGVKGSGYGRFGSKASIAEFTDLRWITIQTGPRH YPI