Protein Info for H281DRAFT_01230 in Paraburkholderia bryophila 376MFSha3.1

Annotation: 3-oxoacyl-[acyl-carrier protein] reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00106: adh_short
  • amino acids 10 to 201 (192 residues), 194.9 bits, E=2.1e-61
• PF01370: Epimerase
  • amino acids 11 to 191 (181 residues), 31.3 bits, E=2.8e-11
• PF08659: KR
  • amino acids 12 to 163 (152 residues), 27.6 bits, E=5e-10
• PF13561: adh_short_C2
  • amino acids 16 to 246 (231 residues), 192.4 bits, E=1.9e-60

Best Hits

Swiss-Prot: 51% identical to KDRDH_SPHSS: 2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD(+)) (LRA5) from Sphingomonas sp. (strain SKA58)

KEGG orthology group: K00059, 3-oxoacyl-[acyl-carrier protein] reductase [EC: 1.1.1.100] (inferred from 96% identity to bpy:Bphyt_5691)

MetaCyc: 56% identical to 2-dehydro-3-deoxy-L-pentonate 4-dehydrogenase (Herbaspirillum huttiense)
RXN-12095 [EC: 1.1.1.401]; 1.1.1.401 [EC: 1.1.1.401]

Predicted SEED Role

"3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100)" in subsystem Fatty Acid Biosynthesis FASII or mycolic acid synthesis (EC 1.1.1.100)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (50/53 steps found)
• palmitate biosynthesis III (28/29 steps found)
• superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
• palmitate biosynthesis II (type II fatty acid synthase) (29/31 steps found)
• anteiso-branched-chain fatty acid biosynthesis (30/34 steps found)
• even iso-branched-chain fatty acid biosynthesis (30/34 steps found)
• odd iso-branched-chain fatty acid biosynthesis (30/34 steps found)
• tetradecanoate biosynthesis (mitochondria) (23/25 steps found)
• superpathway of unsaturated fatty acids biosynthesis (E. coli) (19/20 steps found)
• oleate biosynthesis IV (anaerobic) (14/14 steps found)
• octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) (12/12 steps found)
• palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) (9/9 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (14/16 steps found)
• biotin biosynthesis I (13/15 steps found)
• cis-vaccenate biosynthesis (5/5 steps found)
• fatty acid elongation -- saturated (5/5 steps found)
• gondoate biosynthesis (anaerobic) (4/4 steps found)
• 8-amino-7-oxononanoate biosynthesis I (9/11 steps found)
• L-rhamnose degradation III (6/7 steps found)
• (5Z)-dodecenoate biosynthesis I (5/6 steps found)
• L-arabinose degradation V (5/6 steps found)
• stearate biosynthesis II (bacteria and plants) (5/6 steps found)
• 8-amino-7-oxononanoate biosynthesis IV (4/5 steps found)
• (5Z)-dodecenoate biosynthesis II (4/6 steps found)
• stearate biosynthesis IV (4/6 steps found)
• petroselinate biosynthesis (2/6 steps found)
• 2-allylmalonyl-CoA biosynthesis (2/8 steps found)
• streptorubin B biosynthesis (20/34 steps found)
• mycolate biosynthesis (25/205 steps found)
• superpathway of mycolate biosynthesis (26/239 steps found)

KEGG Metabolic Maps

• Biosynthesis of unsaturated fatty acids
• Fatty acid biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.100

Use Curated BLAST to search for 1.1.1.100 or 1.1.1.401

Protein Sequence (250 amino acids)

>H281DRAFT_01230 3-oxoacyl-[acyl-carrier protein] reductase (Paraburkholderia bryophila 376MFSha3.1)
MNRIDLDGRVVAITGGARGIGYAVAQRALQSGASVALWDVDAERLARSQRELSEFGKVTA
VTVELTQESAVAQAVERTVADHGAIDVLVNCAGITGGNGTTWELEPDVWRRVIDVNLIGP
YLTCRAVVPQMLKQGYGRIVNIASVAGKEGNPNASHYSASKAGLIGLTKSLGKELATKNI
LVNAVTPAAAKTEIFDSMSQQHIDYMLSKIPMNRFLLPEEAASLILWLASEDCAFSTGSV
FDLSGGRATY