Protein Info for H281DRAFT_01202 in Paraburkholderia bryophila 376MFSha3.1

Annotation: methylmalonate-semialdehyde dehydrogenase [acylating]

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01722: methylmalonate-semialdehyde dehydrogenase (acylating)
  • amino acids 9 to 485 (477 residues), 740.6 bits, E=3.6e-227
• PF00171: Aldedh
  • amino acids 17 to 481 (465 residues), 476.9 bits, E=3e-147

Best Hits

Swiss-Prot: 58% identical to MMSA_HUMAN: Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) from Homo sapiens

KEGG orthology group: K00140, methylmalonate-semialdehyde dehydrogenase [EC: 1.2.1.27] (inferred from 95% identity to bug:BC1001_3823)

MetaCyc: 71% identical to methylmalonate-semialdehyde dehydrogenase subunit (Burkholderia cepacia R34)
Methylmalonate-semialdehyde dehydrogenase (acylating). [EC: 1.2.1.27]

Predicted SEED Role

"Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)" in subsystem Isobutyryl-CoA to Propionyl-CoA Module or Valine degradation (EC 1.2.1.27)

MetaCyc Pathways

• myo-inositol degradation I (6/7 steps found)
• β-alanine degradation II (2/2 steps found)
• β-alanine degradation I (1/2 steps found)
• L-valine degradation I (5/8 steps found)
• myo-, chiro- and scyllo-inositol degradation (6/10 steps found)
• propanoyl-CoA degradation II (2/5 steps found)
• 2,4-dinitrotoluene degradation (1/7 steps found)

KEGG Metabolic Maps

• Inositol phosphate metabolism
• Propanoate metabolism
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.27

Use Curated BLAST to search for 1.2.1.27

Sequence Analysis Tools

See A0A2Z5MJ19 at UniProt or InterPro

Protein Sequence (502 amino acids)

>H281DRAFT_01202 methylmalonate-semialdehyde dehydrogenase [acylating] (Paraburkholderia bryophila 376MFSha3.1)
MSAIASNTVKLLINGEFVDSRTTEWRDVVNPATQQVLARVPFATAGEVDEAIRSAHAAFK
TWKDTPIGARMRIMLKYQALIREHMPRIAKTLSAEQGKTIPDAEGDIFRGLEVVEHACSI
GSLQQGEFAENVAGGVDTYTLRQPLGVCAGITPFNFPAMIPLWMFPMAIVCGNTFVLKPS
EQDPMSTMQLVELALEAGVPKGVLNVVHGGKDVVDALCTHELVKAVSFVGSTAVGTHVYR
LGSEHGKRVQSMMGAKNHAVVLPDANREQTLNALAGAGFGAAGQRCMATSVVVLVGAAQQ
WLPEIVAKAKTLKVNAGNEPNTDIGPVVSRAAKERILGLIEAGVKEGATLALDGRDVTVP
GYEQGNFIGPTIFSDVSTEMEIYRTEIFGPVLLVLNAATLDDAIALVNSNPFGNGVGLFT
QSGAAARKFQSEIDVGQVGINIPIPVPVPFFSFTGSRGSKLGDLGPYGKQVVQFYTQTKT
VTARWFDDDTVNDGVNTTISLR