Protein Info for H281DRAFT_01195 in Paraburkholderia bryophila 376MFSha3.1
Annotation: 4-hydroxy-tetrahydrodipicolinate synthase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01714, dihydrodipicolinate synthase [EC: 4.2.1.52] (inferred from 86% identity to bam:Bamb_6107)MetaCyc: 83% identical to Delta1-pyrroline-4-hydroxy-2-carboxylate deaminase subunit (Pseudomonas putida KT2442)
1-pyrroline-4-hydroxy-2-carboxylate deaminase. [EC: 3.5.4.22]
Predicted SEED Role
"1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22)" in subsystem Proline, 4-hydroxyproline uptake and utilization (EC 3.5.4.22)
MetaCyc Pathways
- trans-4-hydroxy-L-proline degradation II (3/4 steps found)
KEGG Metabolic Maps
- Arginine and proline metabolism
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Lysine biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 4.2.1.52
Use Curated BLAST to search for 3.5.4.22 or 4.2.1.52
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (314 amino acids)
>H281DRAFT_01195 4-hydroxy-tetrahydrodipicolinate synthase (Paraburkholderia bryophila 376MFSha3.1) MSNNIFTGTIPALMTPCTADRLPDYDALVAKARELVNLGMSAVVYCGSMGDWPLLTEAQR QEGVARLVAAGIPTIVGTGAVNSKEAISHAAHAAKVGASGLMVIPRVLSRGASPAAQKAH FAAILEAAPALPAVIYNSPYYGFATRADLFFELRGRYPNLIGFKEFGGAADMRYAAEHIT SQDDTVTLMAGVDTQVFHGFVNCGATGAITGIGNALPREVLQLVDLCRKAAKGDVTARRQ ARELESALAVLSSFDEGTDLVLYYKYLMVLNGDTEYSLHFYETDALSEAQRRYAQTQYEL FRNWYAEWSKEVNA