Protein Info for H281DRAFT_01193 in Paraburkholderia bryophila 376MFSha3.1

Annotation: 4-hydroxyproline epimerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 323 PF05544: Pro_racemase" amino acids 6 to 322 (317 residues), 329.9 bits, see alignment E=8e-103

Best Hits

Swiss-Prot: 72% identical to 4HYPE_PSEF5: 4-hydroxyproline 2-epimerase (PFL_1412) from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

KEGG orthology group: K12658, 4-hydroxyproline epimerase [EC: 5.1.1.8] (inferred from 74% identity to bug:BC1001_4119)

MetaCyc: 70% identical to 4-hydroxyproline epimerase subunit (Pseudomonas aeruginosa)
4-hydroxyproline epimerase. [EC: 5.1.1.8]

Predicted SEED Role

"4-hydroxyproline epimerase (EC 5.1.1.8)" in subsystem Proline, 4-hydroxyproline uptake and utilization (EC 5.1.1.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.1.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MPA7 at UniProt or InterPro

Protein Sequence (323 amino acids)

>H281DRAFT_01193 4-hydroxyproline epimerase (Paraburkholderia bryophila 376MFSha3.1)
MNSITVIDSHTGGEPTRLVVEGGPDLGRGPLAERLDIFRRDFDHVRAGVVNEPRGSDVMV
GALLCEPHDTRCSAGVIFFNNVGYLGMCGHGTIGLIVSLAHMGRIKPGVHRIETPVGVVE
AELHGDGSVSVRNVPAYRYRTEVQLDVPGLGRVHGDIAWGGNWFFLVADHGQTLEFANVE
SLTNVTWAIRAALEANGITGEGGALIDHIELFADSTTPGVDSRNFVLCPGKAYDRSPCGT
GTSAKIACLAADAHLAPGATWRQESIIGSIFEASYEPHEDTSHNVDNASRRYVRPSIRGT
AHVSAEAKLIFSADDPFAWGIRA