Protein Info for H281DRAFT_01141 in Paraburkholderia bryophila 376MFSha3.1

Annotation: xanthine dehydrogenase, molybdenum binding subunit apoprotein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1020 PF01315: Ald_Xan_dh_C" amino acids 43 to 153 (111 residues), 94.3 bits, see alignment E=1.8e-30 PF02738: MoCoBD_1" amino acids 169 to 416 (248 residues), 221 bits, see alignment E=3.9e-69 PF20256: MoCoBD_2" amino acids 444 to 758 (315 residues), 240.7 bits, see alignment E=7.2e-75 PF10604: Polyketide_cyc2" amino acids 849 to 981 (133 residues), 47.5 bits, see alignment E=7.2e-16 PF06240: COXG" amino acids 851 to 988 (138 residues), 87.2 bits, see alignment E=2.6e-28 PF03364: Polyketide_cyc" amino acids 855 to 974 (120 residues), 24.6 bits, see alignment E=7.8e-09

Best Hits

KEGG orthology group: K03520, carbon-monoxide dehydrogenase large subunit [EC: 1.2.99.2] (inferred from 91% identity to bpy:Bphyt_2185)

MetaCyc: 82% identical to hmfA (Cupriavidus basilensis)
2-furoyl-CoA dehydrogenase. [EC: 1.3.99.8]

Predicted SEED Role

"Carbon monoxide dehydrogenase large chain (EC 1.2.99.2)" in subsystem CO Dehydrogenase (EC 1.2.99.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.99.2

Use Curated BLAST to search for 1.2.99.2 or 1.3.99.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1020 amino acids)

>H281DRAFT_01141 xanthine dehydrogenase, molybdenum binding subunit apoprotein (Paraburkholderia bryophila 376MFSha3.1)
MNQRDLVSTADAATQDREADAAQGVQRHVGRPMQRLEDPAILTGRGRYGDDIGVRPGTLH
AAVLRSPHAHAELLAIDTQAAAQLQGVRAILTRDDLRAWSRPFVVGVKSPMEQWALAMDR
VRYVGEPVAVVLAETRALAEDALDLIKVEYATLEPVTSIEEAVGDSAVLHEKVGSNVISD
RHFRYGEPEAAFEKAPHRVKLVAHYPRNTCAPIECGVVIAEYLAGDEGYDVTSNFMGPFS
LHAVMAMALNVPANRLRHKAPRDSGGSFGVKQAVFPYVVLMCLASRKAGAPVKWVEDRLE
HLSAATSATARLSTLEAAVENDGRITALSYDQLEDCGAYVRAPEPATFYRMHGCLTGAYA
IDNLLVRNRVVLTSKTPTGLVRGFGGPQVYFALERLMQRIAVELGLDVLDVYRRNFVRAD
AFPYRAAAGALLDSGNYQEALRRALDEGGYDELRARREAARSEGRLYGIGFAAIVEPSIS
NMGYITTVMPAEARRKAGPKSGAIASATVSVDLLGGVVVTIASTPAGQGHMTVCAQVVAD
VLGIAPHEVAVNVEFDTHKDAWSVAAGNYSSRFAGAVAGTVHLAAMRVRDKIARIVSKQL
NCAPQDVRFEGGRIFAQGAEDRAQPFGRVAANAPHWAPALLPEGEEPGLRETVFWNPPNM
AAPDENDRVNTSAAYGFAFDMCGVEVDRATGRVRIDRYVTAHDAGTLLNPALADGQIRGA
FAQGLGAALMEEFRYGADGSFQSGTLADYLMPTACEVPDPVIVHLETPSPFTPLGAKGLG
EGNNMSTPPCIANAVADALGVDDIRLPLTPSKVMALIGIDDPEPSRPELREAPAPKNPAM
SGSGKALTAQGSVDLPATPEAVFAVLLDPKALAKVIPGCHALETEGPNQYRADVTVGVGM
IKARFEAKIGLSEIDAPHRLRLAGAGISSLGSARGSGLVELTPIATGTRLSYDYEAQVSG
KVAAVGARMLEGAAKVVLRQLFESLGRQAAGKPLDASAHSSGEGGGSWLSRLLARFRRQR