Protein Info for H281DRAFT_01136 in Paraburkholderia bryophila 376MFSha3.1

Annotation: 5-(hydroxymethyl)furfural/furfural oxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 582 PF00732: GMC_oxred_N" amino acids 4 to 300 (297 residues), 132.6 bits, see alignment E=3.8e-42 PF05834: Lycopene_cycl" amino acids 5 to 39 (35 residues), 25.1 bits, see alignment (E = 1.9e-09) PF00890: FAD_binding_2" amino acids 202 to 263 (62 residues), 21 bits, see alignment E=3.6e-08 PF05199: GMC_oxred_C" amino acids 367 to 553 (187 residues), 122.8 bits, see alignment E=3.3e-39

Best Hits

KEGG orthology group: K00119, [EC: 1.1.99.-] (inferred from 82% identity to bpy:Bphyt_2180)

Predicted SEED Role

"Choline dehydrogenase (EC 1.1.99.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.1.99.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.99.1

Use Curated BLAST to search for 1.1.99.- or 1.1.99.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (582 amino acids)

>H281DRAFT_01136 5-(hydroxymethyl)furfural/furfural oxidase (Paraburkholderia bryophila 376MFSha3.1)
MEYFDYVIVGGGSAGCVLAQRLSAVPSLRVALIEAGADTPPGRVPPEILDSYPLPVFCGD
TYIWPELTARATRDSAPRVYEQGRVMGGGSSINVQSANRGLPRDYDAWAANGASGWGWED
VLPYFRKLERDVDFPDGELHGKEGPVPIRRIMPADWPPFCNAFATGLRKNGVAPLHDQNA
EFGDGFFPAAFSNLDDRRVSTAIAYLDESTRKRTNLHIHADLRVERIVMEGRVARGVVAL
ARNGERVRFNANEVVLCAGALQSPAMLMHAGIGPKEELNALGIDCVIDLPGVGRNLQDHP
SLTFCHFLAPQLRMPLTRRRASMMAARLSSGIAGGEASDLYLSSATRAAWHELGNRLGLF
FLWCNRPHSRGRVQLVSADPAAPPRVDLNLLDDPRDIARLACGVRTLAKIVAASGLGENS
RDFFPAAFSARVKALSRVGAGNALLTSLLGRLLDGPAPLRRMLIERFFTRGQRLGDLLAD
QAALEDFIRANAFGVWHASGTCRMGDASDPAAVTDTAGSVRGAQGLRVVDASLMPRLPSA
NTNIPTIMMAEKIADAILARRLPGHAGIACRADHRHAFLKVS