Protein Info for H281DRAFT_00537 in Paraburkholderia bryophila 376MFSha3.1

Annotation: DNA mismatch repair protein MutS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 894 TIGR01070: DNA mismatch repair protein MutS" amino acids 14 to 884 (871 residues), 1052.8 bits, see alignment E=0 PF01624: MutS_I" amino acids 15 to 126 (112 residues), 149.1 bits, see alignment E=1.5e-47 PF05188: MutS_II" amino acids 142 to 267 (126 residues), 69.8 bits, see alignment E=7.8e-23 PF05192: MutS_III" amino acids 284 to 578 (295 residues), 155.7 bits, see alignment E=5e-49 PF05190: MutS_IV" amino acids 447 to 538 (92 residues), 110.7 bits, see alignment E=8.5e-36 PF00488: MutS_V" amino acids 628 to 815 (188 residues), 280.2 bits, see alignment E=2.3e-87

Best Hits

Swiss-Prot: 84% identical to MUTS_BURVG: DNA mismatch repair protein MutS (mutS) from Burkholderia vietnamiensis (strain G4 / LMG 22486)

KEGG orthology group: K03555, DNA mismatch repair protein MutS (inferred from 94% identity to bpy:Bphyt_2520)

Predicted SEED Role

"DNA mismatch repair protein MutS" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MAA5 at UniProt or InterPro

Protein Sequence (894 amino acids)

>H281DRAFT_00537 DNA mismatch repair protein MutS (Paraburkholderia bryophila 376MFSha3.1)
MGTQTAAASDVAQHTPMMQQYLRIKAEHPGTLVFYRMGDFYELFFEDAEKAARLLDLTLT
QRGASAGNPIKMAGVPHHAVEQYLAKLVKLGESVAICEQIGDPATSKGPVERKVVRVVTP
GTLTDAALLSDKSDVFLLAMCVAHNRRGVATGVGLAWLNLASGALRLAEVAPDQVAAALE
RIGPAEILVADTAADSASWTPPTGARALTRVPAWHFDVASGTQRLCDQLEVAGLDGFGAH
SLTCACGAAGALLLYAAATQGQQLRHVRSLKVEYESEYIGLDPATRRNLEITQTLRGTES
PTLCSLLDTCCTTMGSRLLRHWLHHPPRDPLVAQSRQQAIGALLEAPAGADVDSLRSALR
HISDIERITGRLALFCARPRDLSSLRDTFAALPELRAKVAAVSSNADSLARIDASLEPPQ
ACVELLTRAIAPEPAAMVRDGGVIARGYDAELDELRDISENCGQFLIDLETRERARTGIG
NLRVEYNKVHGFYIEVTRGQTDKVPDDYRRRQTLKNAERYITPELKTFEDKALSAQERAL
ARERSLYDALLQTLLPFIPDCQRVASALAELDLLTAFAERARALDWVAPSFSPNAGIEIE
QGRHPVVEAQVEQFIANDCTLTPERKLLLITGPNMGGKSTFMRQTALIALLAYVGSYVPA
RRAAFGPIDRIFTRIGAADDLAGGRSTFMVEMTEAAAILNDATPQSLVLMDEIGRGTSTF
DGLALAWAIARHLLSHNGCHTLFATHYFELTQLPAEFPQAANVHLSAVEHGHGIVFLHAV
NEGPANQSYGLQVAQLAGVPNAVIRAARKHLAHLEQQSAAQPTPQLDLFAAPLPMLLEDA
DDERAGSEAPSQSPAMTALVERLRGIDPNDLRPREALDLLYELHELAAAPDADH