Protein Info for H281DRAFT_00524 in Paraburkholderia bryophila 376MFSha3.1

Annotation: protease FtsH subunit HflC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF01145: Band_7" amino acids 24 to 200 (177 residues), 104 bits, see alignment E=4.8e-34 TIGR01932: HflC protein" amino acids 140 to 282 (143 residues), 136.9 bits, see alignment E=3.5e-44

Best Hits

KEGG orthology group: K04087, membrane protease subunit HflC [EC: 3.4.-.-] (inferred from 91% identity to bgf:BC1003_1212)

Predicted SEED Role

"HflC protein" in subsystem Hfl operon

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.-.-

Use Curated BLAST to search for 3.4.-.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MA19 at UniProt or InterPro

Protein Sequence (300 amino acids)

>H281DRAFT_00524 protease FtsH subunit HflC (Paraburkholderia bryophila 376MFSha3.1)
MNKIIALVIAVVIVLFAASSMVFVVDQRHMAVLSPRGDAAPTLLGPGLHVKLPPPLQTVT
LVDNRIQSLDAPDEDRYVTSDKNDLLANPVVKYRVTDPLKLLTETKGDVQSLPDRIALVA
RSALGDAFGKYTLSDALAKQQALADEARAAMAKSAASLGVSVVDVQLTRVDVPASMADSV
YKRMIAEREQAAADERAKGAAEADKIRADAVAQQQAILADGYRQAQTIKGEGDANAAEIA
AQAYGSDPEFYQFYQSMQAYRKTFKPGDVIVVDPSNEFFRFMRSSTGGLAPDASAAPRKH