Protein Info for H281DRAFT_00381 in Paraburkholderia bryophila 376MFSha3.1

Annotation: dihydropyrimidinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02033: dihydropyrimidinase
  • amino acids 4 to 459 (456 residues), 576.8 bits, E=1.7e-177
• PF01979: Amidohydro_1
  • amino acids 54 to 415 (362 residues), 91.7 bits, E=5.6e-30

Best Hits

Swiss-Prot: 68% identical to HYDA_PSEAE: D-hydantoinase/dihydropyrimidinase (dht) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K01464, dihydropyrimidinase [EC: 3.5.2.2] (inferred from 97% identity to bug:BC1001_2383)

MetaCyc: 46% identical to dihydropyrimidinase (Arabidopsis thaliana col)
Dihydropyrimidinase. [EC: 3.5.2.2]

Predicted SEED Role

"Dihydropyrimidinase (EC 3.5.2.2)" in subsystem Hydantoin metabolism or Pyrimidine utilization (EC 3.5.2.2)

MetaCyc Pathways

• thymine degradation (3/3 steps found)
• uracil degradation I (reductive) (3/3 steps found)
• superpathway of pyrimidine ribonucleosides degradation (4/5 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Pantothenate and CoA biosynthesis
• Pyrimidine metabolism
• beta-Alanine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.2

Sequence Analysis Tools

See A0A2Z5MAY7 at UniProt or InterPro

Protein Sequence (483 amino acids)

>H281DRAFT_00381 dihydropyrimidinase (Paraburkholderia bryophila 376MFSha3.1)
MTTLIRGGTIIDAENTYRADVLCADPQDGGTILQIGADLEAPAGAAIVDAGGQYVMPGGI
DPHTHMELPFMGTTASDDFYTGTAAGLSGGTTSIIDFVIPGPKQSLMEAFKQWRGWAEKA
SADYGFHVAVTWWDDSVYRDMGSLVHEHGVSSFKHFMAYKNAIMADDEVLVNSFSRSLEL
GALPTVHAENGELVFQLQRQLLAKGFTGPEAHPLSRPPEVEGEAANRAIRIAQVLGVPVY
IVHVSAKDAVDAISRARSEGLRVFGEVLPGHLVIDEAVYRDPDWTRAAAHVMSPPFRSAE
HREALWRGLQAGQLHTTATDHCVFCASQKAMGREDFTKIPNGCGGVEDRMAVLWHHGVNS
GRLTPNEFVRITSTNAAQIFNLYPRKGAVRVGADADIVVWDPNASKTISVKTHHQKVDFN
VFEGMTVQGVAMHTLTRGALAWTNGDLRAVRGAGQYQKRPPNAAYFDAIRVSNKLKEPHP
IER