Protein Info for H281DRAFT_00307 in Paraburkholderia bryophila 376MFSha3.1
Annotation: Acyl-CoA reductase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K00155, [EC: 1.2.1.-] (inferred from 96% identity to bxe:Bxe_A3297)MetaCyc: 40% identical to 3-sulfolactaldehyde dehydrogenase (Alkalicoccus urumqiensis)
RXN-17101 [EC: 1.2.1.97]
Predicted SEED Role
"Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12)" in subsystem Arginine and Ornithine Degradation or Proline, 4-hydroxyproline uptake and utilization (EC 1.5.1.12)
MetaCyc Pathways
- L-proline degradation I (3/3 steps found)
- L-arginine degradation I (arginase pathway) (2/3 steps found)
- ethene biosynthesis II (microbes) (1/4 steps found)
- sulfoquinovose degradation III (1/4 steps found)
- sulfoquinovose degradation II (1/5 steps found)
- sulfoquinovose degradation VI (1/5 steps found)
KEGG Metabolic Maps
- 1- and 2-Methylnaphthalene degradation
- Arginine and proline metabolism
- Geraniol degradation
- Glutamate metabolism
- Limonene and pinene degradation
- Lysine biosynthesis
- Naphthalene and anthracene degradation
- Tryptophan metabolism
- Urea cycle and metabolism of amino groups
Isozymes
Compare fitness of predicted isozymes for: 1.2.1.-, 1.5.1.12
Use Curated BLAST to search for 1.2.1.- or 1.2.1.97 or 1.5.1.12
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A2Z5M9S1 at UniProt or InterPro
Protein Sequence (478 amino acids)
>H281DRAFT_00307 Acyl-CoA reductase (Paraburkholderia bryophila 376MFSha3.1) MLNKTYPYYLANQAVAANTDLEVTDKFSGEVATRVAMADAAAIDKAIGFAVEAMPAMRAF APFKRQAVLEHCVKRFRERYDELALALCIEAGKPINDSKGEVTRLIDTFKVAAEEAVRID GEIVNLQISPRANGYHGYVKRVPIGPCSFISPFNFPLNLTAHKVAPAIAAGVPFVLKPAS RTPVGALIMGEILAETDLPKGAFSILPAHRDGADLFTTDERFKLLSFTGSPAVGWELKKK AGKKKVILELGGNAAAIVDGDQGGKLDYVVDRLAFGAFYQSGQSCIGVQRILVHASIYDA LREKLIAKTRSLVMGDPKDEKTFVGPMISESESKRLAGWMESAVQAGATIVAGGKVDGAM FEATLLEGVKRDTDLYRKEAFGPVAILERFDDFGAALATVNDSDFGLQAGVFTDSLAHAH RAWDELEVGGVVINDVPSFRVDNMPYGGVKDSGLGREGVRYAIEDMTELRLMVMRETW