Protein Info for H281DRAFT_00192 in Paraburkholderia bryophila 376MFSha3.1

Annotation: metabolite-proton symporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 435 transmembrane" amino acids 34 to 53 (20 residues), see Phobius details amino acids 62 to 83 (22 residues), see Phobius details amino acids 95 to 116 (22 residues), see Phobius details amino acids 122 to 148 (27 residues), see Phobius details amino acids 161 to 185 (25 residues), see Phobius details amino acids 195 to 215 (21 residues), see Phobius details amino acids 245 to 264 (20 residues), see Phobius details amino acids 284 to 305 (22 residues), see Phobius details amino acids 315 to 335 (21 residues), see Phobius details amino acids 341 to 364 (24 residues), see Phobius details amino acids 376 to 396 (21 residues), see Phobius details amino acids 407 to 426 (20 residues), see Phobius details PF00083: Sugar_tr" amino acids 23 to 233 (211 residues), 95.1 bits, see alignment E=4.7e-31 amino acids 261 to 432 (172 residues), 41.8 bits, see alignment E=7.1e-15 PF07690: MFS_1" amino acids 27 to 379 (353 residues), 94.3 bits, see alignment E=7.2e-31 amino acids 287 to 426 (140 residues), 48.3 bits, see alignment E=7.1e-17

Best Hits

Swiss-Prot: 54% identical to YHJE_ECOLI: Inner membrane metabolite transport protein YhjE (yhjE) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 98% identity to bug:BC1001_0812)

Predicted SEED Role

"Permeases of the major facilitator superfamily"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2Z5MA20 at UniProt or InterPro

Protein Sequence (435 amino acids)

>H281DRAFT_00192 metabolite-proton symporter (Paraburkholderia bryophila 376MFSha3.1)
MSTSPISAAEPNAAGHTNSARIIFASFIGTAIEFYDFYVYATAAALVIGPVFFPHGSATA
QALSAFVTFGIAFVARPIGSFLFGHFGDRIGRKSTLVASLLVMGVSTTLIGFVPGYDSIG
SLAPILLCILRFGQGIGLGGEWGGAALLATENAPAGKRGWFGMFPQLGPSIGFLASNGLF
FALAMSLSDAQFRSWGWRVPFLVSAVLVALGLYVRLKIAETPAFQAAIERQERVKVPIAT
LLSRHWVPTLLGALAMVVCYTLFYNATTFSLSYGVSVLHIPRQTFLGLLCIAVVFMALAT
PLSAWASDRYGRKPVLIVGIVAAVLSGFTMAPLLGSGQTPLVLLFLVIELFLMGVTFAPM
GALLPELFPTNVRYTGAGVSYNLGGILGASVAPYIAQMLAARGGLPWVGAYVSIAAAVSM
IGVLCMRETRDSRLM