Protein Info for H281DRAFT_00143 in Paraburkholderia bryophila 376MFSha3.1

Annotation: L-threonine O-3-phosphate decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 368 transmembrane" amino acids 228 to 245 (18 residues), see Phobius details TIGR01140: threonine-phosphate decarboxylase" amino acids 36 to 356 (321 residues), 340.7 bits, see alignment E=4.4e-106 PF00155: Aminotran_1_2" amino acids 84 to 349 (266 residues), 103.3 bits, see alignment E=8.7e-34

Best Hits

KEGG orthology group: K02225, cobalamin biosynthetic protein CobC (inferred from 85% identity to bug:BC1001_0762)

Predicted SEED Role

"L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)" in subsystem Cobalamin synthesis or Coenzyme B12 biosynthesis (EC 4.1.1.81)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.81

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (368 amino acids)

>H281DRAFT_00143 L-threonine O-3-phosphate decarboxylase (Paraburkholderia bryophila 376MFSha3.1)
MSERMDERRSLQHIDEPGHAGEAPAACASPGATIVHGGNLHEAAERYRIPYPEWLDLSTG
INPHGYPVPPVPADAWRRLPDEGDDLAECAARYYGAPDAAHVLSVAGSQAAIRTLPALLP
RAVAGVAPLTYSEYAPAFQRAGHRVVPLDVSWDVLPDSLTHVAVVNPNNPTAGHLSASKL
LAWHAQLSARGGTLLVDEAFADTMPDASLAAFTDRDGLIVLRSPGKFFGLAGVRAGFVLA
APALLDSLRRVLGAWTVSGPARHAVRAALLDHAWQQQMRTRLEADSARLVDLLQVHGIRT
RSTPLFAWTDDPRAAALHEALATRGVWTRLFASSGSVRFGLPASEDEWTRLAHTLRAAVE
TIHATRPA