Protein Info for Ga0059261_3851 in Sphingomonas koreensis DSMZ 15582

Annotation: DNA ligase, ATP-dependent, PP_1105 family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 522 TIGR04120: DNA ligase, ATP-dependent, PP_1105 family" amino acids 2 to 520 (519 residues), 773.1 bits, see alignment E=8.7e-237 PF01068: DNA_ligase_A_M" amino acids 216 to 395 (180 residues), 115.3 bits, see alignment E=3e-37 PF04679: DNA_ligase_A_C" amino acids 416 to 506 (91 residues), 44.1 bits, see alignment E=2.4e-15

Best Hits

KEGG orthology group: K01971, DNA ligase (ATP) [EC: 6.5.1.1] (inferred from 67% identity to sch:Sphch_0779)

Predicted SEED Role

"ATP-dependent DNA ligase (EC 6.5.1.1) LigC" in subsystem DNA Repair Base Excision (EC 6.5.1.1)

Isozymes

Compare fitness of predicted isozymes for: 6.5.1.1

Use Curated BLAST to search for 6.5.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2M8WHY6 at UniProt or InterPro

Protein Sequence (522 amino acids)

>Ga0059261_3851 DNA ligase, ATP-dependent, PP_1105 family (Sphingomonas koreensis DSMZ 15582)
LKRFAALIDRLIYTRSRNTKLALIADYLRHTPDPDRGWAIAALTETLDFPAVKSAMVRAL
LATRVDEELFRLSRHFVGDTAETAALLWPDALRKQDDPSVSEAVAALSAATRADAPQVVA
GLLDRLDADGRYALLKLALGGMRIGVSARLAKQAFAQAFDVQIDDVEEVWHAIPPPYAPI
FAWGEGRAARPDLSDLPFFRPFMLAHPLEAGSVDLDDYAAEWKWDGIRVQIVHGGGETRI
YSRGGEEISGAFPELIAAFDQDAVIDGELLVRGDAQGGEAASFNALQQRLGRKTVSKQML
AEYPAFVRVYDLLAVDGEDLRSLAWHDRRRRLETFLPRLAASHFDLSQVIDAKDWDDLAA
RRTGARDAAIEGVMLKRRDAPYVPGRRAGLWYKWKRDPLTADCVMMYAQRGNGRRASFYS
DYTFGCWSDAGELLPVGKAYSGFTDEELKWLDNFVRNHTVARFGPVREVEKTLVLEVVFD
SIHLSKRHKSGLAMRFPRILRIRRDKPAEEADRVATLRVMAS