Protein Info for Ga0059261_3596 in Sphingomonas koreensis DSMZ 15582

Annotation: acetyl-CoA carboxylase, carboxyl transferase, alpha subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00513: acetyl-CoA carboxylase, carboxyl transferase, alpha subunit
  • amino acids 2 to 314 (313 residues), 399.1 bits, E=7.9e-124
• PF03255: ACCA
  • amino acids 5 to 146 (142 residues), 191 bits, E=1e-60
• PF01039: Carboxyl_trans
  • amino acids 100 to 254 (155 residues), 65.6 bits, E=3.7e-22

Best Hits

Swiss-Prot: 74% identical to ACCA_SPHWW: Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA) from Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)

KEGG orthology group: K01962, acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC: 6.4.1.2] (inferred from 74% identity to swi:Swit_0618)

MetaCyc: 50% identical to acetyl-CoA carboxyltransferase subunit alpha (Escherichia coli K-12 substr. MG1655)
RXN0-5055 [EC: 2.1.3.15]

Predicted SEED Role

"Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2)" in subsystem Fatty Acid Biosynthesis FASII (EC 6.4.1.2)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (48/53 steps found)
• superpathway of fatty acid biosynthesis II (plant) (37/43 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (13/16 steps found)
• biotin-carboxyl carrier protein assembly (4/4 steps found)
• fatty acid biosynthesis initiation (type II) (3/3 steps found)
• propanoyl CoA degradation I (3/3 steps found)
• superpathway of fatty acid biosynthesis initiation (4/5 steps found)
• methylaspartate cycle (14/19 steps found)
• 2-oxobutanoate degradation I (3/4 steps found)
• 3-hydroxypropanoate cycle (9/13 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (12/18 steps found)
• fatty acid biosynthesis initiation (type I) (1/3 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (6/10 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (11/17 steps found)
• superpathway of the 3-hydroxypropanoate cycle (10/18 steps found)
• candicidin biosynthesis (1/6 steps found)
• glyoxylate assimilation (6/13 steps found)
• jadomycin biosynthesis (3/9 steps found)
• superpathway of L-methionine salvage and degradation (7/16 steps found)
• superpathway of candicidin biosynthesis (3/11 steps found)
• superpathway of mycolate biosynthesis (19/239 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis
• Propanoate metabolism
• Pyruvate metabolism
• Tetracycline biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 6.4.1.2

Use Curated BLAST to search for 2.1.3.15 or 6.4.1.2

Sequence Analysis Tools

See A0A2M8WH68 at UniProt or InterPro

Protein Sequence (315 amino acids)

>Ga0059261_3596 acetyl-CoA carboxylase, carboxyl transferase, alpha subunit (Sphingomonas koreensis DSMZ 15582)
MATFLEFEKPIAELQARIDELRDAAAGGEVDIDSEVAKLQAKSDKFLRDAYARLTPWQKT
LVARHPERPHFKHYVARLIDDFMPLGGDRAFADDAAIQGGLGRFRGQRVMVIGHEKGDDT
ASRLKHNFGMGKPEGYRKAIRLVELAGKFGIPVITLVDTSGAFPGMEAEERGQAEAIARS
TEACLNAGVPLIASILGEGGSGGAVALAAGNRVLMMEHAVYSVISPEGCASILWRTADKA
PEAAEAMKVTAQHLKELGVIDTIVPEPLGGAHRDRDAAIDALGNAIESALKELSGQSPES
LRQSRRAKFLAMGRA