Protein Info for Ga0059261_3591 in Sphingomonas koreensis DSMZ 15582

Annotation: 3-dehydroquinate synthase (EC 4.2.3.4)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01357: 3-dehydroquinate synthase
  • amino acids 13 to 356 (344 residues), 348 bits, E=3e-108
• PF00465: Fe-ADH
  • amino acids 16 to 176 (161 residues), 31.6 bits, E=1.2e-11
• PF13685: Fe-ADH_2
  • amino acids 17 to 186 (170 residues), 38.7 bits, E=1.5e-13
• PF01761: DHQ_synthase
  • amino acids 67 to 330 (264 residues), 312.7 bits, E=2.5e-97

Best Hits

Swiss-Prot: 62% identical to AROB_RUEPO: 3-dehydroquinate synthase (aroB) from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)

KEGG orthology group: K01735, 3-dehydroquinate synthase [EC: 4.2.3.4] (inferred from 74% identity to sjp:SJA_C1-24040)

Predicted SEED Role

"3-dehydroquinate synthase (EC 4.2.3.4)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) or Type IV pilus (EC 4.2.3.4)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• chorismate biosynthesis I (7/7 steps found)
• 3-dehydroquinate biosynthesis I (2/2 steps found)
• superpathway of chorismate metabolism (37/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.3.4

Sequence Analysis Tools

See A0A2M8WH86 at UniProt or InterPro

Protein Sequence (366 amino acids)

>Ga0059261_3591 3-dehydroquinate synthase (EC 4.2.3.4) (Sphingomonas koreensis DSMZ 15582)
MRTVPVALGARSYEVRIESGLLGRAAEQLAPFVRKRPFVIVTDANVAPHGERLAANLAAA
GIASETIILPPGEGTKSWTQLESLLDRLLDLGIERGDHVIALGGGVIGDLVGFASAILKR
GCNFVQIPTTLLAQVDSSVGGKTAINARAGKNLVGAFHQPSVVLIDPDLLDTLPLREQRA
GYAEVVKYGLIDDADFFAWCEGNGAALLAGDPNAREYAIAHSVGAKARIVADDERETTGR
RALLNLGHTFGHALEAETGFSDQLLHGEGVAAGMALAFAFSARQGLCPATDAERVAAHLK
ASGLPHDLASAGIATNGARLVEHMLHDKKMDAGTLPFLLTRGIGATYLDKQVNLADVETF
LDELPR