Protein Info for Ga0059261_3287 in Sphingomonas koreensis DSMZ 15582
Annotation: Topoisomerase IB
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K03168, DNA topoisomerase I [EC: 5.99.1.2] (inferred from 66% identity to sjp:SJA_C1-07430)Predicted SEED Role
"DNA topoisomerase IB (poxvirus type) (EC 5.99.1.2)" in subsystem DNA topoisomerases, Type I, ATP-independent (EC 5.99.1.2)
Isozymes
Compare fitness of predicted isozymes for: 5.99.1.2
Use Curated BLAST to search for 5.99.1.2
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A2M8WGC2 at UniProt or InterPro
Protein Sequence (339 amino acids)
>Ga0059261_3287 Topoisomerase IB (Sphingomonas koreensis DSMZ 15582) MKHGLRYCDDSRPGITRRKLSQGWGYWDTDGHRITNRDEIDRLNAVGLPPAYTDAWYCPH PNGHLQATGIDARGRKQYRYHPEFRAAQEAAKYDRCAAFGHLLPGLRARIEADLRKRSLS KERAVAAVVRLLDRGHVRVGNEGYAKANKSFGATTLRKRHAKLNGTSLKLQYRAKSGKLR TLTLTDTSLRSFVKRCQDLPGQHLFGWLDGAGEAHPVTSTDVNDYIRDAMGDDFTAKHFR TWGASVIAFEALVDAEAPIGLNTMLEPVTEALGNTPAIARKSYVHPQLIELAKDRDAQRA FRDALTLPRATRHLSRAERGLIAFLEHNAMAAPSARNAA