Protein Info for Ga0059261_1694 in Sphingomonas koreensis DSMZ 15582

Annotation: homogentisate 1,2-dioxygenase (EC 1.13.11.5)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 441 TIGR01015: homogentisate 1,2-dioxygenase" amino acids 9 to 434 (426 residues), 659.7 bits, see alignment E=8.5e-203 PF20510: HgmA_N" amino acids 11 to 281 (271 residues), 389.7 bits, see alignment E=7.1e-121 PF04209: HgmA_C" amino acids 283 to 434 (152 residues), 240.2 bits, see alignment E=7.9e-76

Best Hits

Swiss-Prot: 70% identical to HGD_SINFN: Homogentisate 1,2-dioxygenase (hmgA) from Sinorhizobium fredii (strain NBRC 101917 / NGR234)

KEGG orthology group: K00451, homogentisate 1,2-dioxygenase [EC: 1.13.11.5] (inferred from 80% identity to pgv:SL003B_3062)

Predicted SEED Role

"Homogentisate 1,2-dioxygenase (EC 1.13.11.5)" in subsystem Homogentisate pathway of aromatic compound degradation (EC 1.13.11.5)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.13.11.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2M8WBV3 at UniProt or InterPro

Protein Sequence (441 amino acids)

>Ga0059261_1694 homogentisate 1,2-dioxygenase (EC 1.13.11.5) (Sphingomonas koreensis DSMZ 15582)
MASHNMQAVGYMPGFGNDFETEALPGALPQGQNSPQKCPYGLYAEQLSGTAFTAPRGQNE
RSWCYRIRPSVRHVGRFAAIELPHWKSAPNIVPGVASLGQYRWNPVPHGAGELTWLTGMR
TVTTAGDVNTQTGMASHVYLVTASMVDSYFYSADGELLVVPQEGRLRFCTELGVIEIAPG
EIAVLPRGLVYRVEVIDGPCRGFVCENYGQPFALPDRGPIGANCMANPRDFKTPVAAFED
RETPSTLTIKWCGQFHQSAIPHSPLDVVAWHGNYAPYKYDLSTYSPVGAILFDHPDPSIF
TVLTARSEIPGTANIDFVLFRERWLVAEHSFRPPWYHKNVMSELMGNIYGEYDAKPDGFA
PGGMSLHNCMLPHGPDRNAFEKASNAALKPEKLDKTMSFMFETRFPQHLTDWAAREAPLQ
SDYADCWDGLDKKFDGSIDPA