Protein Info for Ga0059261_1693 in Sphingomonas koreensis DSMZ 15582

Annotation: fumarylacetoacetate hydrolase (EC 3.7.1.2)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 419 TIGR01266: fumarylacetoacetase" amino acids 6 to 411 (406 residues), 501.8 bits, see alignment E=7.4e-155 PF09298: FAA_hydrolase_N" amino acids 21 to 117 (97 residues), 82.4 bits, see alignment E=2.5e-27 PF01557: FAA_hydrolase" amino acids 123 to 407 (285 residues), 138.5 bits, see alignment E=2.6e-44

Best Hits

KEGG orthology group: K01555, fumarylacetoacetase [EC: 3.7.1.2] (inferred from 73% identity to sit:TM1040_2622)

Predicted SEED Role

"Fumarylacetoacetase (EC 3.7.1.2)" in subsystem Homogentisate pathway of aromatic compound degradation or Salicylate and gentisate catabolism (EC 3.7.1.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.7.1.2

Use Curated BLAST to search for 3.7.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2M8WBV4 at UniProt or InterPro

Protein Sequence (419 amino acids)

>Ga0059261_1693 fumarylacetoacetate hydrolase (EC 3.7.1.2) (Sphingomonas koreensis DSMZ 15582)
MSPLRSWVAAANAADTDFPLNNLPYGVFSDATRGPRCGVAIGDRILDMAALEAAGLLRLG
DVPLFAEPGWNTLMAQGPAVWGALRAQLIALLAEGAAERVAVEPHLVPMAGAQLHLPFRV
AGYTDFYASRQHAFNVGTMFRGAENALPPNWLHIPIGYNGRASSVVVSGTDVRRPWGQVK
GPEDAAPRFAPSARFDIELELGAIVGTGSSDPLTVAEADAMIFGYVLLNDWSARDIQAWE
YQPLGPFQGKATATTISPWIVTAAALEPFRAHGPAREKPLLPYLDEPGPMLYDIDLEVGL
TPEGGAESVISRTSYREMYYSAAQQLAHHSTAGCRMEVGDLLGTGTISGPDKGSFGSLLE
LSWGGKEPLTLAGGAQRSFVEDGDTLILRGQCRGDGYRIGFGDCSGTVIPAFEDPYRRS