Protein Info for Ga0059261_1044 in Sphingomonas koreensis DSMZ 15582

Annotation: imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00475: IGPD
  • amino acids 31 to 174 (144 residues), 228 bits, E=2.4e-72

Best Hits

Swiss-Prot: 77% identical to HIS7_SPHAL: Imidazoleglycerol-phosphate dehydratase (hisB) from Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256)

KEGG orthology group: K01693, imidazoleglycerol-phosphate dehydratase [EC: 4.2.1.19] (inferred from 78% identity to sjp:SJA_C1-15560)

Predicted SEED Role

"Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)" in subsystem Histidine Biosynthesis (EC 4.2.1.19)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (43/46 steps found)
• L-histidine biosynthesis (10/10 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Histidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.19

Sequence Analysis Tools

See A0A2M8WA54 at UniProt or InterPro

Protein Sequence (195 amino acids)

>Ga0059261_1044 imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) (Sphingomonas koreensis DSMZ 15582)
MRTATISRKTSETAVDVTVNLDGTGSYAISTGIGFFDHMLEQLSRHSLIDLEVKTVGDLH
IDQHHTVEDTGLAIGEAVAKALGDKRGIRRYADALSPMDETLTRVAIDISGRPYLVWKTQ
FSQKRLGEMDTEMFEHWFHSFAQTAGVTLHIETLYGTNNHHIAEAAFKGLARALRQAVEI
DPRKADAIPSTKGTL