Protein Info for Ga0059261_1006 in Sphingomonas koreensis DSMZ 15582

Annotation: NAD-dependent aldehyde dehydrogenases

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 2 to 449 (448 residues), 447.3 bits, E=2.8e-138

Best Hits

Swiss-Prot: 52% identical to GABD1_MYCBO: Succinate-semialdehyde dehydrogenase [NADP(+)] 1 (gabD1) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 63% identity to eli:ELI_12665)

MetaCyc: 52% identical to NADP-dependent succinate-semialdehyde dehydrogenase (Mycobacterium tuberculosis H37Rv)
SUCCSEMIALDDEHYDROG-RXN [EC: 1.2.1.79]

Predicted SEED Role

"Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16)" (EC 1.2.1.16, EC 1.2.1.24)

MetaCyc Pathways

• TCA cycle IV (2-oxoglutarate decarboxylase) (8/9 steps found)
• 4-aminobutanoate degradation IV (2/3 steps found)
• superpathway of 4-aminobutanoate degradation (2/3 steps found)
• 4-aminobutanoate degradation I (1/2 steps found)
• 4-aminobutanoate degradation II (1/2 steps found)
• 4-aminobutanoate degradation III (1/2 steps found)
• N-methylpyrrolidone degradation (1/3 steps found)
• GABA shunt I (1/4 steps found)
• GABA shunt II (1/4 steps found)
• 4-hydroxyphenylacetate degradation (3/8 steps found)
• superpathway of L-arginine and L-ornithine degradation (6/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (4/11 steps found)
• nicotine degradation II (pyrrolidine pathway) (2/11 steps found)
• nicotine degradation I (pyridine pathway) (4/17 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Tyrosine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.24 or 1.2.1.79

Sequence Analysis Tools

See A0A1L6JHG9 at UniProt or InterPro

Protein Sequence (453 amino acids)

>Ga0059261_1006 NAD-dependent aldehyde dehydrogenases (Sphingomonas koreensis DSMZ 15582)
MFTSINPATGEAGATFAALDDDAIEAALTRAEAAFRSWRASDIAQRTALLTAIADRFEAN
KRHLAETATKEMGKTLASAIAEVEKCIAGFRHYADKGPGYLAPIETKTASGRAVGHWLPL
GPILAVMPWNFPYWQVVRWLAPTILAGNVGLLKHASLTQGCAALIQQMVSAAGAPDGLFQ
NLPIKSDKVSRIIADTRVAAVTLTGSEGAGAKVAEAAGRALKKVVLELGGSDPFIVMPSA
DLDKAVATAVKARVQNAGQSCICAKRMIVHADVYDAFLDKFTAAMLAVKIGDPMEDGVEM
GPLSSVEQRDTVLEQVERAVADGATLAGGAKIERDGAWMEAGVLTHVHPDADFAQEEIFG
PVAMVFRADDIDAAIALANDVPFGLGSSVWTSDQAEIDRFVRDIESGMTAVNQLLASTPE
APFGGVKLSGHGRELGPWGLHEFMNLKAVMLAD