Protein Info for Ga0059261_0875 in Sphingomonas koreensis DSMZ 15582

Annotation: Leucyl aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 491 PF02789: Peptidase_M17_N" amino acids 31 to 138 (108 residues), 42.8 bits, see alignment E=4.6e-15 PF00883: Peptidase_M17" amino acids 176 to 481 (306 residues), 410.3 bits, see alignment E=5.5e-127

Best Hits

Swiss-Prot: 50% identical to AMPA_RHOPA: Probable cytosol aminopeptidase (pepA) from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

KEGG orthology group: K01255, leucyl aminopeptidase [EC: 3.4.11.1] (inferred from 72% identity to swi:Swit_0412)

Predicted SEED Role

"Cytosol aminopeptidase PepA (EC 3.4.11.1)" (EC 3.4.11.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.1

Use Curated BLAST to search for 3.4.11.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2M8W9S2 at UniProt or InterPro

Protein Sequence (491 amino acids)

>Ga0059261_0875 Leucyl aminopeptidase (Sphingomonas koreensis DSMZ 15582)
MRVTFSAARPADAGVVALPVEKDGIDRIPAGVLDDATLALARGAAKAGRFEGEAGGIVEI
FVPGSDGANRLVLLGVGSGSEADYERAGGALTARYLTSGVTAIAIDLASLGGAPTARAAA
RLAAAAVQRGWRHDVYRTRLTDKQKPTLAEIVVAGAADGTEAAYAEQAAVTEGLDLTRGL
VSDPPNIVYPESFVERCRHLAELGVEIEVLDRAAMEKLGMGALLGVAQGSVREARLLAMR
WNGKGEGDVDLALVGKGVTFDTGGISIKPAAGMEDMKWDMGGAGAVAGAMKALAARKAKA
NVIGVCGLVENMPDGNAQRPGDVVTSMSGQTIEVINTDAEGRLVLCDAITWVQKVHAPKT
IVDLATLTGAMIISLGSEHGGLFANDDGLADELLAAGRATGDLLWRFPLGDAYNKLIDSP
IADMKNVGPRGAGSITAAQFIQRFVGEGVRWAHLDIAGMVWADKPGSTYDKGATGYGVRL
LDRFVRDNFER