Protein Info for Ga0059261_0436 in Sphingomonas koreensis DSMZ 15582

Annotation: The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1059 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 341 to 361 (21 residues), see Phobius details amino acids 368 to 389 (22 residues), see Phobius details amino acids 395 to 415 (21 residues), see Phobius details amino acids 436 to 459 (24 residues), see Phobius details amino acids 471 to 498 (28 residues), see Phobius details amino acids 545 to 563 (19 residues), see Phobius details amino acids 879 to 897 (19 residues), see Phobius details amino acids 904 to 926 (23 residues), see Phobius details amino acids 932 to 953 (22 residues), see Phobius details amino acids 981 to 1002 (22 residues), see Phobius details amino acids 1009 to 1035 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1036 (1033 residues), 1157.8 bits, see alignment E=0 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 4 to 1045 (1042 residues), 1159.9 bits, see alignment E=0 PF02355: SecD_SecF" amino acids 343 to 498 (156 residues), 20.5 bits, see alignment E=2.8e-08

Best Hits

KEGG orthology group: None (inferred from 63% identity to avn:Avin_33870)

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2M8W8E7 at UniProt or InterPro

Protein Sequence (1059 amino acids)

>Ga0059261_0436 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family (Sphingomonas koreensis DSMZ 15582)
MNFPRFFIDRPIFAIVLSVLLLIAGLLALLRLPLSEYPAVAPPTVTVVAAYPGASPEVIA
ETVASPIEQAVNGVEGMLYMSSQAATDGRMTLTVTFAQGTDPDIAQVQVQNRVSRALPRL
PETVQRLGVTTQKVAPDALMVVHLLSPSKRYDPLFISNYALLQVRDEIARIPGIADVVVW
GAGEYSMRVWLDPARIASRGLTASDIVAAIRAQNVEVAAGSVGRQPNPAAAQQVALDVKG
RLATEEEFAAIVVKTGADGQLTRLGEVARIEMGANDYALRSLLDGEPAIALQILQSPGAN
ALDTAAEVRATMDRLSGQFPDGLEHRIAYDPTIFVEASIESVIVTLIEATLLVVLVVILF
LQTWRASIIPLVAVPVSLVGTLAVMYLFGFSLNTLSLFGLVLSIGIVVDDAIVVVENVER
HIGLGESPREAARKAMAEVTGPIIAITSVLAAVFIPTAFLGGLQGEFYRQFALTVAISTI
LSAVNSLTLSPALAAVLLQRHDAPRDGLQRGIDKGFGWLFRPFNRAFDRGSLAYVGGVQR
VIRRGAVAGLTYAGLLGLTWFAFDKLPAGFVPAQDKYYLVGIVQLPNGASLDRTQAVAEQ
VSKIALAEPGVESVVAFPGLSINGFVNVPNAAVMFVMLDPFSERTSPDMAAGAIAGRLQG
KYAAVPDGFVGVFPPPPVPGLGATGGFKMQIEDRSGAGYEALAAASAKVMAAAAKEPALA
GLMTSYNVASPELSVDVDRTKAAAQGVAMTDVFDTMQVYLGSLYVNDFNRFGRTYQVYAQ
AEADARAQPDAVGRLQVRNAQGNMVPLATLVTTAPGAGPDRIIHYNGFPSADISGGPAPG
FSSGQAVAAMERIARAELPEGMTFEWTDLTFQEKTAGNAALYIFPLAVLLAFLILAAQYN
SWTLPLAVLLIVPMCLLSALVGVWLTGGDINIFTQIAFVVLVGLAAKNAILIVEFARAQE
DDGLDPLAAALEACRLRLRPILMTSIAFIAGAVPLAIATGAGAEMRQAMGIAVFAGMLGV
TLFGLFLTPLFYVVIRKAVLRREARRLSHPDAKPQELTQ