Protein Info for Ga0059261_0362 in Sphingomonas koreensis DSMZ 15582

Annotation: beta-ketoacyl-acyl-carrier-protein synthase II

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00109: ketoacyl-synt
  • amino acids 1 to 253 (253 residues), 197.3 bits, E=3.6e-62
• TIGR03150: beta-ketoacyl-acyl-carrier-protein synthase II
  • amino acids 2 to 417 (416 residues), 613 bits, E=1e-188
• PF02801: Ketoacyl-synt_C
  • amino acids 261 to 375 (115 residues), 131.6 bits, E=1.5e-42

Best Hits

Swiss-Prot: 59% identical to FABF_RHIME: 3-oxoacyl-[acyl-carrier-protein] synthase 2 (fabF) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K09458, 3-oxoacyl-[acyl-carrier-protein] synthase II [EC: 2.3.1.179] (inferred from 86% identity to sjp:SJA_C1-16080)

MetaCyc: 56% identical to 3-oxoacyl-[acyl carrier protein] synthase 2 (Escherichia coli K-12 substr. MG1655)
Beta-ketoacyl-acyl-carrier-protein synthase II. [EC: 2.3.1.179, 2.3.1.41]; 2.3.1.179,2.3.1.41 [EC: 2.3.1.179, 2.3.1.41]; 2.3.1.179,2.3.1.41 [EC: 2.3.1.179, 2.3.1.41]; 2.3.1.179 [EC: 2.3.1.179, 2.3.1.41]

Predicted SEED Role

"3-oxoacyl-[acyl-carrier-protein] synthase, KASII (EC 2.3.1.179)" (EC 2.3.1.179)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (48/53 steps found)
• palmitate biosynthesis II (type II fatty acid synthase) (29/31 steps found)
• superpathway of fatty acid biosynthesis II (plant) (37/43 steps found)
• oleate biosynthesis IV (anaerobic) (13/14 steps found)
• superpathway of unsaturated fatty acids biosynthesis (E. coli) (17/20 steps found)
• biotin biosynthesis I (13/15 steps found)
• palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) (8/9 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (13/16 steps found)
• gondoate biosynthesis (anaerobic) (4/4 steps found)
• 8-amino-7-oxononanoate biosynthesis I (9/11 steps found)
• (5Z)-dodecenoate biosynthesis I (5/6 steps found)
• cis-vaccenate biosynthesis (4/5 steps found)
• fatty acid elongation -- saturated (4/5 steps found)
• superpathway of fatty acid biosynthesis initiation (4/5 steps found)
• octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) (9/12 steps found)
• palmitate biosynthesis III (21/29 steps found)
• (5Z)-dodecenoate biosynthesis II (4/6 steps found)
• stearate biosynthesis II (bacteria and plants) (4/6 steps found)
• anteiso-branched-chain fatty acid biosynthesis (24/34 steps found)
• even iso-branched-chain fatty acid biosynthesis (24/34 steps found)
• odd iso-branched-chain fatty acid biosynthesis (24/34 steps found)
• fatty acid biosynthesis initiation (mitochondria) (2/4 steps found)
• stearate biosynthesis IV (3/6 steps found)
• petroselinate biosynthesis (2/6 steps found)
• streptorubin B biosynthesis (20/34 steps found)
• tetradecanoate biosynthesis (mitochondria) (12/25 steps found)
• mycolate biosynthesis (18/205 steps found)
• superpathway of mycolate biosynthesis (19/239 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.179 or 2.3.1.41

Sequence Analysis Tools

See A0A1L6JBE5 at UniProt or InterPro

Protein Sequence (419 amino acids)

>Ga0059261_0362 beta-ketoacyl-acyl-carrier-protein synthase II (Sphingomonas koreensis DSMZ 15582)
MRRVVVTGLGLVTPLGADVETAWKNIIASKSGAGTITRFDATDFHSNYACEVKPADHEYG
FDPGKRVDHKVQRQVDPFIVYGIDAAGQAIEDAGLTDMTDEERLRAGCSIGSGIGGLPGI
ESESLVLAEKGPKRVSPHFVHGRLINLISGQVSIKYGLMGPNHAVVTACSTGAHSIGDAA
RMIAMDDADVMLAGGAEGAICPIGIAGFGQARALSTGFRDEPWRASRPWDEGRDGFVMGE
GAGVVVLEEYERAKARGAKIYAEVVGYGLSGDAYHVTAPHPEGSGAFRSMQMAMKKSGLD
LSDIDYINAHGTSTPLGDELELGAVRKLFGNAIGDLSMSSTKSAIGHLLGGAGAVESIFC
ILAMRDGIVPPTLNLDNPSENCAGVDLVPHVAKERKVKAVLNNSFGFGGTNASLVMKAV