Protein Info for Ga0059261_0171 in Sphingomonas koreensis DSMZ 15582

Annotation: Thiol-disulfide isomerase and thioredoxins

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 175 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF00578: AhpC-TSA" amino acids 37 to 153 (117 residues), 47.2 bits, see alignment E=2.1e-16 PF08534: Redoxin" amino acids 37 to 171 (135 residues), 57.9 bits, see alignment E=1e-19

Best Hits

KEGG orthology group: K02199, cytochrome c biogenesis protein CcmG, thiol:disulfide interchange protein DsbE (inferred from 58% identity to sjp:SJA_C1-17480)

Predicted SEED Role

"Cytochrome c-type biogenesis protein CcmG/DsbE, thiol:disulfide oxidoreductase" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2M8W7P3 at UniProt or InterPro

Protein Sequence (175 amino acids)

>Ga0059261_0171 Thiol-disulfide isomerase and thioredoxins (Sphingomonas koreensis DSMZ 15582)
VKRWTLWVPLVIFLAVVVLAAWRLTATGEAVVKSALVGKPLPEFSLPAMVDGKPGLSRRD
LATGKPRLLNVFASWCVPCIAEAPQLLKLKAAGVEIDAVAIKDSPEAVKAFLSRHGDPYA
RIGDDRDRIVQIGIGSSGVPETFVIDGQGRIAAQHIGDIRAEDVPELLKALEAAE