Protein Info for Ga0059261_0102 in Sphingomonas koreensis DSMZ 15582

Annotation: endopeptidase La

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 797 PF02190: LON_substr_bdg" amino acids 4 to 195 (192 residues), 181.1 bits, see alignment E=7.7e-57 TIGR00763: endopeptidase La" amino acids 6 to 766 (761 residues), 966.6 bits, see alignment E=6.1e-295 PF08298: AAA_PrkA" amino acids 316 to 368 (53 residues), 25.2 bits, see alignment 2.5e-09 PF07728: AAA_5" amino acids 348 to 481 (134 residues), 34.2 bits, see alignment E=7.4e-12 PF00004: AAA" amino acids 348 to 485 (138 residues), 74.7 bits, see alignment E=2.9e-24 PF05362: Lon_C" amino acids 565 to 767 (203 residues), 313.2 bits, see alignment E=2.1e-97 PF13541: ChlI" amino acids 612 to 735 (124 residues), 31.7 bits, see alignment E=3.8e-11

Best Hits

Swiss-Prot: 66% identical to LON_AZOBR: Lon protease (lon) from Azospirillum brasilense

KEGG orthology group: K01338, ATP-dependent Lon protease [EC: 3.4.21.53] (inferred from 83% identity to swi:Swit_0390)

MetaCyc: 61% identical to Lon protease (Escherichia coli K-12 substr. MG1655)
Endopeptidase La. [EC: 3.4.21.53]

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type I" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1L6JBW4 at UniProt or InterPro

Protein Sequence (797 amino acids)

>Ga0059261_0102 endopeptidase La (Sphingomonas koreensis DSMZ 15582)
MKSTYPVLPLRDIVVFPHMIVPLFVGRDKSVAALEAAMNDDKEIFLVAQLDPANDDPGRD
DLYEIGVSAEVMQLLKLPDGTVRVLVAGKERGKLEGMEETGGFLTATVSPVDEKTVEGNE
IQALMRSAVDQFENYAKLNRKLPAETAVQLGEIEEASRLADAIAGNIAVKVADKQSLLVE
TDPQKRLEMVFAFMEGELGVLQVEKKIRSRVKRQMEKTQREYYLNEQLKAIQRELGNEGE
EGEGDEIAELTQKIATLKLSKEARAKAQGELKKLKTMAPMSAEATVVRNYLDVLLGLPWG
KKSKLKKDLVEAEAVLDADHYGLEKVKDRIVEYLAVQARTNKLKGPILCLVGPPGVGKTS
LGKSIAKATGREFIRQSLGGVRDEAEIRGHRRTYIGSLPGKVVSNLKKAGTSNPLFLLDE
IDKLGQDFRGDPASALLEVLDPEQNSKFNDHYLEIDVDLSDVMFVTTANSLNLPQPLLDR
MEIIRLEGYTEDEKVEIARRHLIEKQIEAHGLKEGEFTLTDEGLRALIQKYTREAGVRTL
EREIAKLARKALRKILEGKAESVTITPDNLSEFAGVQKYRHGLGEDENQIGAVTGLAWTE
VGGELLTIESVTVPGKGAIKTTGKLGDVMKESVEAAFSFIKARSPAYGIKPSIFARKDIH
IHLPEGAVPKDGPSAGIGIVTAIVSTLTGVPVRKDVAMTGEVTLRGRVLPIGGLKEKLLA
ALRGGITTVLIPQENEKDLAEIPANIREGLTIVPVSHVDAVLKLALTEPLAAIDWTEADE
LAAQPPVSTSGSEPLRH