Protein Info for Ga0059261_0036 in Sphingomonas koreensis DSMZ 15582

Annotation: DNA gyrase, A subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 913 TIGR01063: DNA gyrase, A subunit" amino acids 13 to 880 (868 residues), 1111.2 bits, see alignment E=0 PF00521: DNA_topoisoIV" amino acids 37 to 500 (464 residues), 533.4 bits, see alignment E=4.5e-164 PF03989: DNA_gyraseA_C" amino acids 532 to 579 (48 residues), 44.7 bits, see alignment 7.4e-16 amino acids 584 to 631 (48 residues), 28.4 bits, see alignment 8.9e-11 amino acids 642 to 685 (44 residues), 13.5 bits, see alignment 4.2e-06 amino acids 692 to 738 (47 residues), 51.6 bits, see alignment 5e-18 amino acids 784 to 827 (44 residues), 27 bits, see alignment 2.5e-10 amino acids 834 to 879 (46 residues), 40.5 bits, see alignment 1.5e-14

Best Hits

KEGG orthology group: K02469, DNA gyrase subunit A [EC: 5.99.1.3] (inferred from 79% identity to sjp:SJA_C1-21310)

Predicted SEED Role

"DNA gyrase subunit A (EC 5.99.1.3)" in subsystem DNA topoisomerases, Type II, ATP-dependent or Resistance to fluoroquinolones (EC 5.99.1.3)

Isozymes

Compare fitness of predicted isozymes for: 5.99.1.3

Use Curated BLAST to search for 5.99.1.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A2M8W7D9 at UniProt or InterPro

Protein Sequence (913 amino acids)

>Ga0059261_0036 DNA gyrase, A subunit (Sphingomonas koreensis DSMZ 15582)
LTDETVLADPSDITPISIVDEMKTSYLDYAMSVIVARALPDVRDGLKPVHRRILYAAQEG
GYLPGRAYRKSARLVGDVMGKYHPHGDSSIYDAMARMAQDWAMRVPLIDGQGNFGSMDPD
PPAAMRYTEARLAKVAMSLLDDIDKDTVDFQDNYDGSESEPTVLPARYPNLLVNGAGGIA
VGMATNIPPHNLGEVIDACLAYMDNGAVSIEELMEIVPGPDFPTGAMILGRSGCRSAYQT
GRGSIIVRSRHTFEQRGERRSIVLTEIPYQQGKNALVEKIAEAAKEKRVEGVSDIRDESS
REGVRIVIDLKRDATPEVVLNQIWRNTPAQSSFPANMLAIRGGRPELLNLRDIVEAFVKF
REQVITRRSKFELAKARDRAHILLGLVIAVTNLDEVVRIIRSSSSPVAAREALLMREWPI
AEIAPYIRLVEAVETEVTGEAYRLSDIQVRAILDLRLHRLTALGRDEIGDELKELADSIA
ELLEILANRAKLYEVLREELVAVRDQYATPRRTEIAPAADGIEDEDLIEREDMVVTVTMQ
GYIKRTTLDTFRAQARGGKGRAGMATKDEDVVTELFVTSTHTPVLFFSTLGKVYRMKVWK
LPEGGPATRGRPMINLLPLAAGETISTVLPLPEDEAEWGKLHVMFATAKGSVRRNSMDAF
TNVPSNGKIAMKFEGEDEDDRLIGVALLDESDDVLLATRQGKAIRFPGDDVREFQSRNST
GVRGMRLAQGDEVISLSILHKAGIKDQEERDDYLRHAPWKADKDSEPQMTPERFEELKAK
EQFILTVCANGYGKLSSAYEYRRTGRGGQGITNIDNIARNGLVVASFPATQAHQLMLVTD
QAKMIRLPLTSLRVIGRGSAGVRLFNVADNEHVVSAARIEEPEDEETVAVEGEGPESPDA
TSATDVADPEGNA