Protein Info for PGA1_c09610 in Phaeobacter inhibens DSM 17395

Annotation: UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase MurG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 83% identical to MURG_RUEPO: UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (murG) from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)

KEGG orthology group: K02563, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC: 2.4.1.227] (inferred from 83% identity to sil:SPO1195)

Predicted SEED Role

"UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227)" in subsystem Peptidoglycan Biosynthesis (EC 2.4.1.227)

MetaCyc Pathways

peptidoglycan biosynthesis I (meso-diaminopimelate containing) (11/12 steps found)
peptidoglycan biosynthesis III (mycobacteria) (11/15 steps found)
peptidoglycan biosynthesis II (staphylococci) (12/17 steps found)
peptidoglycan biosynthesis IV (Enterococcus faecium) (12/17 steps found)
peptidoglycan biosynthesis V (β-lactam resistance) (11/17 steps found)

KEGG Metabolic Maps

Peptidoglycan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.1.227

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7EXS8 at UniProt or InterPro

Protein Sequence (365 amino acids)

>PGA1_c09610 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase MurG (Phaeobacter inhibens DSM 17395)
MAQKLLLMAAGGTGGHMFPAQALAEAMLRRGWRVKLSTDARGARYTGGYPHTTEITEVSS
ATFARGGVLAKAMVAPKIAAGVTRMALQMRRDRPDVVVGFGGYPSIPALGAATLLKLPRM
IHEQNGVLGRVNQLFATRVAGVACGVWPTALPEGVDGVHVGNPVRAAVLERAGAGYIPPG
DYPMSVLVMGGSQGARILSDVVPGAIAALPEALRSRLRVSHQARDEDGARVTQFYAEHGI
SADVQPFFADVPARMSEAQLVISRSGASSVADIAVIGRPSILIPFAAAAGDHQSANARGL
VDAGAAILIPESALDVSALTEQMSAVLSNPDGASQMARAALQVGIPDATERLVGLVEQLS
EEGMT