Protein Info for HP15_889 in Marinobacter adhaerens HP15

Annotation: cobalamin synthesis protein/P47K family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 328 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF02492: cobW" amino acids 6 to 181 (176 residues), 144.4 bits, see alignment E=1.5e-46

Best Hits

KEGG orthology group: None (inferred from 68% identity to maq:Maqu_2162)

Predicted SEED Role

"Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PEU8 at UniProt or InterPro

Protein Sequence (328 amino acids)

>HP15_889 cobalamin synthesis protein/P47K family protein (Marinobacter adhaerens HP15)
MAQPIPTSLILGFLGVGKTTAILDLLKSKPENEVWAVLVNEFGEVGIDGAMLKTEGAFIK
EIPGGCMCCVAGLPMQIGLNQLIHKAKPDRLLIEPTGLGHPSQILDTLTSEHYQDVLAMG
PVICLVDPRRLEEPKVLGNVQFRDQVAAADILVANKTDLCTPEQLTHFDEWAAQLEPAKR
AIHHTRFGHLAPGWLDGQSDALPVTDPEAHHHHHHKTASPAPAIDDEPWQQITNQGQGHF
SVGWRIHPELILDENALLVMAMDSAFVRFKAVVQTVDGWRAINVVDGALTVIQGEPQAYS
RAEIIASDQIDARELDARMRAAAGLDPR