Protein Info for PGA1_c08870 in Phaeobacter inhibens DSM 17395

Annotation: riboflavin biosynthesis protein RibD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 358 TIGR00326: riboflavin biosynthesis protein RibD" amino acids 1 to 350 (350 residues), 347.4 bits, see alignment E=9.5e-108 PF00383: dCMP_cyt_deam_1" amino acids 1 to 93 (93 residues), 58.4 bits, see alignment E=8.7e-20 PF14437: MafB19-deam" amino acids 20 to 98 (79 residues), 41.1 bits, see alignment E=2.5e-14 TIGR00227: riboflavin-specific deaminase C-terminal domain" amino acids 140 to 350 (211 residues), 178.9 bits, see alignment E=1e-56 PF01872: RibD_C" amino acids 141 to 350 (210 residues), 149 bits, see alignment E=2.3e-47

Best Hits

KEGG orthology group: K11752, diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC: 1.1.1.193 3.5.4.26] (inferred from 78% identity to sit:TM1040_2135)

Predicted SEED Role

"Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193)" in subsystem Riboflavin, FMN and FAD metabolism (EC 1.1.1.193, EC 3.5.4.26)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.193 or 3.5.4.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7EK81 at UniProt or InterPro

Protein Sequence (358 amino acids)

>PGA1_c08870 riboflavin biosynthesis protein RibD (Phaeobacter inhibens DSM 17395)
MSLALSLGRRGQGNCWPNPAVGCVIVRDGRIVGRGWTQPGGRPHAEPQALQQAGDLARGA
TVYVSLEPCSHTGKTPPCAQALINAGVARVVAAIEDSDPRVSGHGFAMLRDAGIPVTTGV
CSDAAAWDHAGFFLKTEQGRPFVTLKLASSFDGRIATAAGESKWITGSEARRAVHAMRAR
HDAVMVGGGTARADDPSLTVRDLGVARQPVRVVISRHLDLPLMGQLARSARDIPVWICHG
AGADAERLRAWEGLGAVLLPCAADGLQLDAGDVLQQLGQAGLTRVFCEGGSALAASLLAQ
DLVDELIGFTAGLGIGGDGLSSIGSLGLDALAEAPRFDLIDVRPVGADIQHRWTRSLR