Protein Info for HP15_845 in Marinobacter adhaerens HP15

Annotation: sensory box/GGDEF family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 758 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details transmembrane" amino acids 301 to 319 (19 residues), see Phobius details TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 335 to 489 (155 residues), 120.1 bits, see alignment E=4e-39 PF00990: GGDEF" amino acids 338 to 486 (149 residues), 126.8 bits, see alignment E=6.9e-41 PF00563: EAL" amino acids 508 to 742 (235 residues), 251.7 bits, see alignment E=6.7e-79

Best Hits

KEGG orthology group: None (inferred from 65% identity to maq:Maqu_2182)

Predicted SEED Role

"Predicted signal transduction protein" in subsystem Flagellar motility

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PR74 at UniProt or InterPro

Protein Sequence (758 amino acids)

>HP15_845 sensory box/GGDEF family protein (Marinobacter adhaerens HP15)
MAILKRNLWTLFALILLGGVLLLSAVLFFRWQGLISDEKLYQTARVELVAQSVDSILRTQ
ELVLDVIGRELLNQDNLLSGSRQIPLLDSILAANPMLVGFGLARPDGTLVRVSTNLDLST
LPNLRTDPETRDSFLGALSSDAMVVGRTYFVDALGAWVIPIRKAIRSPSGEVVAVMTAGM
RLDGRGSVFGKTLHDGDSDTVMLFRETDGYVQFMSADGIGPQQYSQIRVPMDQREINRAA
FEKELGKSVEEVMQGSDSVVIRTRRQGEDYLTAAVFNARYQLWSISETRFAPLYREFLQS
LLQYLLTFLVFGIVFYKGFRIIDNAEKKRRLELSYLSRHDDLTGLLNRNGLLDRLDNLVP
DRKPFCLIVINIDNFKGINDRFGLETGDETLLEFGRRLAELVESRDDLARLGGDEYAIVT
PNTNLDDVEKACVSLAGNLSRTFEVGRLRLQVTASIGVACFPNDGDSLSKLIRSAHLALY
EAKQSRNDVCIYRSEMEMAYLRRLSVEQRLRYGLASGSLYMVYQPQVDQTGKAVGLEALV
RWQDEELGFVSPAEFVEVAEKSGLMVPLGRFVLETSIREYSLFRNEVGGSVDLSINISVI
QFRQPDFVETVLEVLAMHRVSPGELVLEITESLFMSDFERVLKTIERLREKGIRISMDDF
GTGYSSLSLLRKLPLDELKIDKSFVDTILEDEKAANMIRSIIAIARSHNMELVAEGVEEE
AQASALVEMGCRRFQGYYFSRPETLDRLKANPALAIGH