Protein Info for HP15_788 in Marinobacter adhaerens HP15

Annotation: multi-sensor hybrid histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 957 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 174 to 196 (23 residues), see Phobius details PF09984: sCache_4" amino acids 35 to 175 (141 residues), 80.2 bits, see alignment E=4.3e-26 PF00672: HAMP" amino acids 197 to 247 (51 residues), 29.5 bits, see alignment 2.3e-10 PF00512: HisKA" amino acids 292 to 356 (65 residues), 84.1 bits, see alignment 1.7e-27 PF02518: HATPase_c" amino acids 403 to 518 (116 residues), 95.6 bits, see alignment E=7.9e-31 PF00072: Response_reg" amino acids 684 to 796 (113 residues), 87.6 bits, see alignment E=1.9e-28 PF01627: Hpt" amino acids 855 to 935 (81 residues), 36.4 bits, see alignment E=1.6e-12

Best Hits

KEGG orthology group: K07678, two-component system, NarL family, sensor histidine kinase BarA [EC: 2.7.13.3] (inferred from 83% identity to maq:Maqu_2241)

Predicted SEED Role

"BarA sensory histidine kinase (= VarS = GacS)" in subsystem Type III secretion system orphans

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PQK9 at UniProt or InterPro

Protein Sequence (957 amino acids)

>HP15_788 multi-sensor hybrid histidine kinase (Marinobacter adhaerens HP15)
MRRWGIRKKVLVVTLVPTLLTTLMLGLFFTYSWVNNIESLLKDRGESLSRQLAAGSEYGL
FTANRSLLSSLSNALLEEQDVRSITFFGSDGSRLLHTGPGSSETVQATELTAEHATRISR
ENSTRFITPVFLQDLMIESMLDPDARQSMSNLREPLGWVVVEMSHIRTEKETYKALLISL
LLILGGVILSMAIALRLSRAFTNPVFELNEAVARLKEGKLDTRVYTGAGPEFEQLESGLN
AMAEELSKAQAEMQQNIDQATEDLRETLETIEIQNIELDFARKEALEASRIKSEFLANMS
HEIRTPLNGIIGFTELLLKSPLPRQQRDHLSTIRKSSEILLTIINDILDFSKIEAGKLIL
DRVPFQLRDIVEEVMVMLAPAAHAKNLDLVPLVYNDVPDNIMGDPLRVKQVITNLVNNAI
KFTQTGEVVLRASLEEEEADTNRVTLRLSITDSGVGLSRAQQQSLFNAFSQADASTARQY
GGTGLGLAISKRLVEEMGGKIGLESELGKGSTFWFTLTSELATSGEAIAPRDALRGERVI
YLEQQKTTGLAVEHLLRDWGMVVDRVASPGALQEHIEEAQKSQAGYAVAILGITRHLLNS
SQYCGLVRTLEIERDCRTLLLTPTLETHDTPLSGLASGHLTKPVCRDSLYDELLLLVHGI
NSGGRVPEYEISANRATTANVPRVLAVDDNDANLKLVMTLLEDCQLDAESASSGFEALSK
ARQKPFDLVFMDLQMPGMDGVETTARLREMDTGNHRTPIIALTAHALADEQERLTKQGFD
GYMPKPISSGQLNDIIHEYTGYVCPKNGSDGRLPVPEVRDTRRALRPSTRKMQQDCVSVD
ESIQLAAGKADLAEELFSMLLEQVHVDRGRISELWASHSMDELLECVHKLHGATRYCGVP
ELRAAANHLETAIKCSAPDLEHQKDQLLSAMERLQIWSDQTDWQQLFRERHEAAETT