Protein Info for HP15_764 in Marinobacter adhaerens HP15

Annotation: homoserine dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03447: NAD_binding_3
  • amino acids 10 to 127 (118 residues), 84 bits, E=2.6e-27
• PF00742: Homoserine_dh
  • amino acids 135 to 312 (178 residues), 214.1 bits, E=2.7e-67
• PF01842: ACT
  • amino acids 351 to 417 (67 residues), 59.4 bits, E=4.6e-20
• PF13291: ACT_4
  • amino acids 353 to 417 (65 residues), 27.8 bits, E=6.7e-10

Best Hits

Swiss-Prot: 66% identical to DHOM_PSEAE: Homoserine dehydrogenase (hom) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K00003, homoserine dehydrogenase [EC: 1.1.1.3] (inferred from 88% identity to maq:Maqu_2274)

Predicted SEED Role

"Homoserine dehydrogenase (EC 1.1.1.3)" in subsystem Methionine Biosynthesis or Threonine and Homoserine Biosynthesis (EC 1.1.1.3)

MetaCyc Pathways

• aspartate superpathway (23/25 steps found)
• superpathway of L-isoleucine biosynthesis I (13/13 steps found)
• superpathway of L-methionine biosynthesis (by sulfhydrylation) (12/12 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (16/18 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• superpathway of L-threonine biosynthesis (6/6 steps found)
• L-homoserine biosynthesis (3/3 steps found)
• superpathway of S-adenosyl-L-methionine biosynthesis (7/9 steps found)
• superpathway of L-methionine biosynthesis (transsulfuration) (7/9 steps found)
• superpathway of L-homoserine and L-methionine biosynthesis (6/8 steps found)

KEGG Metabolic Maps

• Biosynthesis of plant hormones
• Glycine, serine and threonine metabolism
• Lysine biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.3

Use Curated BLAST to search for 1.1.1.3

Sequence Analysis Tools

See E4PQI5 at UniProt or InterPro

Protein Sequence (433 amino acids)

>HP15_764 homoserine dehydrogenase (Marinobacter adhaerens HP15)
MKDVSVGICGLGTVGGGTFNVLTRNARLIAGRAGCNIRITRVASRRAREDMDLGDVPFST
DIYDVVNDPDVDIVVELIGGYDAAKELVLAAIRNGKHVVTANKALIAVHGNEIFEAAEKA
GVVVAYEAGVAGGIPVIKAVREGMAANRIDWIAGIINGTGNYILTEMRAGREFSEVLKEA
QDLGYAEADPTFDVEGIDAAHKLTILASAGFGVPLQFEKGFTEGISKITPYDIAHAELLG
YRIKHLGIARRRDDGIELRVHPTLVPQSHLIAQVDGVLNAVLVDGDAVGQTMYYGPGAGD
EATGSAVIADIVDVARAVATESKLRVPYLGFSPDAMEDLDVLSMEDIQSAYYLRITALDR
PGVLAKIASILSEHGINIESIMQKESELKDGRIPVIILTHTVQERQINRAIEELEALSDT
DGHVVRIRAENFN