Protein Info for HP15_763 in Marinobacter adhaerens HP15

Annotation: protein-disulfide isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 266 signal peptide" amino acids 1 to 48 (48 residues), see Phobius details PF10411: DsbC_N" amino acids 48 to 116 (69 residues), 65 bits, see alignment E=5.7e-22 PF13098: Thioredoxin_2" amino acids 138 to 261 (124 residues), 82.2 bits, see alignment E=5.8e-27

Best Hits

KEGG orthology group: K03981, thiol:disulfide interchange protein DsbC [EC: 5.3.4.1] (inferred from 79% identity to maq:Maqu_2275)

Predicted SEED Role

"Thiol:disulfide interchange protein DsbC" in subsystem Periplasmic disulfide interchange

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.4.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PQI4 at UniProt or InterPro

Protein Sequence (266 amino acids)

>HP15_763 protein-disulfide isomerase (Marinobacter adhaerens HP15)
MIPGLCQYCPGCLTAYWKRLFARMNMKHVVVALGVVLGAFGAASVSAGEVEDRISERLTQ
AVPGLKVVSVKESEAKGLYEVQSNNGDTIYATEDGQYLMTGDLLKITDQGIANVTEAART
EARREMMADYGNKGVISFPAKNEKAVVNVFTDIDCPYCRKLHDEVPQLNDYGITVNYYAF
PRSGPNTASFKKYESVWCADDQQAAMDAAKAGRSVPDASCENPVGEQYELGGRVGVTGTP
AIVLEDGNMVRGYVPAQRLAEGLGLL