Protein Info for PGA1_c07810 in Phaeobacter inhibens DSM 17395
Annotation: aminotransferase class-III
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 61% identical to DOED_HALED: Diaminobutyrate--2-oxoglutarate transaminase (doeD) from Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9)
KEGG orthology group: K00837, [EC: 2.6.1.-] (inferred from 84% identity to sit:TM1040_2691)MetaCyc: 61% identical to diaminobutanoate--2-oxoglutarate transaminase (Halomonas elongata DSM 2581)
Predicted SEED Role
"Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC 2.6.1.19)" (EC 2.6.1.19)
MetaCyc Pathways
- 4-aminobutanoate degradation I (2/2 steps found)
- 4-aminobutanoate degradation III (2/2 steps found)
- GABA shunt I (3/4 steps found)
- GABA shunt II (3/4 steps found)
- superpathway of 4-aminobutanoate degradation (2/3 steps found)
- 4-aminobutanoate degradation II (1/2 steps found)
- superpathway of L-arginine and L-ornithine degradation (7/13 steps found)
- superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)
- 4-aminobutanoate degradation V (2/7 steps found)
- nicotine degradation I (pyridine pathway) (4/17 steps found)
KEGG Metabolic Maps
- Alanine and aspartate metabolism
- Aminophosphonate metabolism
- Arginine and proline metabolism
- Butanoate metabolism
- Caprolactam degradation
- Glutamate metabolism
- Lysine biosynthesis
- Lysine degradation
- Methionine metabolism
- Nucleotide sugars metabolism
- Propanoate metabolism
- beta-Alanine metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.6.1.-
Use Curated BLAST to search for 2.6.1.- or 2.6.1.19
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See I7DYH4 at UniProt or InterPro
Protein Sequence (457 amino acids)
>PGA1_c07810 aminotransferase class-III (Phaeobacter inhibens DSM 17395) MLRNDQLDQWDRDSFFHPSTHLAEFARGNLPQRVVTGGTGCHIEDRDGNRMLDAFAGLYC VNVGYGRPEIAEAIADQARELAYYHSYVGHGTEASITLAKMIMDRAPDHMSKVYFGLSGS DANETNIKLIWYYNNILGRPEKKKIISRWRGYHGSGLMTGSLTGLELFHNKFDLPLAQVV HTESPYYFRREDLSQSEADFVAHCVAELEALIAREGADTIAAFIGEPVLGTGGIVPPPAG YWPAIQAVLERHDILLVADEVVTGFGRLGTMFGSDHYGMRPDLITIAKGLTSAYAPLSGS IVSDKMWQVLERGTDENGPIGHGWTYSAHPIGAAAGVANLKLIDQLGLVENAGAIGAYLN DEMRKALGDHPNVGDLRGEGMLCAVEFVADRDDRRFFDASDKIGPQIAAKLLEQDSVIAR AMPQGDILGFAPPFCLTRDEADRVVAATHRAVTAVLG